ArticleArquivos brasileiros de cardiologia2021
Clusters of Cardiometabolic Risk Factors and Their Association with Atherosclerosis and Chronic Inflammation among Adults and Elderly in Florianópolis, Southern Brazil.
Article in Arquivos brasileiros de cardiologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Latent Profiles of Modifiable Biological Factors and Their Associations with Lifestyle Factors and Cardiovascular Disease Outcomes.Journal of clinical medicine · 2026Article
- Association between Cardiovascular Risk Factors and Carotid Plaques in a Population-Based Study - The SHIP-Brazil Study.Arquivos brasileiros de cardiologia · 2025Article
- Cardiometabolic Risk Clusters and Their Reproductive Correlates: A Latent Class Analysis of Indian Women.Global heart · 2025Article
- Unveiling the Link between MASLD-Associated Liver Fibrosis and Subclinical Atherosclerosis.Arquivos brasileiros de cardiologia · 2025Article
- Translational Medicine and Implementation Science.Sao Paulo medical journal = Revista paulista de medicina · 2024Article
- Translational Medicine and Implementation Science: How to Transform What We Know Into What We Do.Arquivos brasileiros de cardiologia · 2022Article
- Interleukin 35 (IL35): A New Biomarker for Coronary Artery Disease?Arquivos brasileiros de cardiologia · 2022Article
- Low-normal serum unconjugated bilirubin levels are associated with late but not early carotid atherosclerotic lesions in T2DM subjects.Frontiers in endocrinology · 2022Article
- Impact of Highly Saturated versus Unsaturated Fat Intake on Carbohydrate Metabolism and Vascular Reactivity in Rat.Biochemistry research international · 2022Article
- Anti-Inflammatory Effects of Atorvastatin Therapy in Metabolic Syndrome.Arquivos brasileiros de cardiologia · 2021Article
- The Importance of Recognizing the Co-Occurrence of Cardiometabolic Risk Factors in the Population to Establish Priorities in Public Policies.Arquivos brasileiros de cardiologia · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe significant increase in cardiovascular diseases in developing countries alerts about their impact on underprivileged populations.
objectiveTo identify the relationship of clusters of metabolic syndrome (MS) components with atherosclerosis and chronic inflammation among adults and elderly.
methodsCross-sectional analysis using data from two population-based cohort studies in Florianópolis, Southern Brazil (EpiFloripa Adult Cohort Study, n = 862, 39.9±11.5 years; EpiFloripa Aging Cohort Study, n = 1197, 69.7±7.1 years). Blood pressure (BP), waist circumference (WC), and lipid and glucose levels were analyzed as individual factors or as clusters (either as the number of components present in an individual or as combinations of components). Outcomes included carotid intima-media thickness (IMT), atherosclerotic plaques, and C-reactive protein (CRP) levels. Multiple linear and logistic regression analyses adjusted for confounding factors were used. The statistical significance adopted was 5%.
resultsIndividuals with high BP, elevated WC, dyslipidemia and hyperglycemia (6.1% of the sample) showed higher IMT and CRP than those negatives for all MetS components. Elevated WC was a common determinant of systemic inflammation, while the coexistence of high BP and elevated WC (clusters of two or three factors) was associated with higher IMT (β between +3.2 and +6.1 x 10-2 mm; p value < 0.05) and CRP (EXPβ between 2.18 and 2.77; p value < 0.05).
conclusionThe coexistence of high BP and elevated WC was associated with increased IMT and CRP levels, but central obesity affected systemic inflammation either alone or in combination with other risk factors.
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