Evidence map›Paper›PMID 34322378›Full record

ArticleFrontiers in oncology2021

The SPOP-ITCH Signaling Axis Protects Against Prostate Cancer Metastasis.

Jinlu Ma, Mengjiao Cai, Yaqi Mo, Joshua S Fried, Xinyue Tan, Yuan Ma, Jie Chen, Suxia Han, Bo Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Molecular insights for the tumor suppressor role of SPOP in prostate cancer.Biochimica et biophysica acta. Reviews on cancer · 2026
    Review
  3. Review
  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jinlu MaDepartment of Radiation Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Mengjiao CaiDepartment of Radiation Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Yaqi MoDepartment of Biochemistry and Molecular Biology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Joshua S FriedDepartment of Oncology, Southern Research Institute, and University Alabama at Birmingham, Birmingham, AL, United States.
Xinyue TanDepartment of Radiation Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Yuan MaDepartment of Radiation Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Jie ChenDepartment of Oncology, Southern Research Institute, and University Alabama at Birmingham, Birmingham, AL, United States.
Suxia HanDepartment of Radiation Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Bo XuDepartment of Biochemistry and Molecular Biology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
First Affiliated Hospital of Xi'an Jiaotong University · CNSouthern Research Institute · USChongqing University · CNTianjin Medical University Cancer Institute and Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer is one of the most common causes of cancer incidence and death in men, with the mortality caused primarily by the late-stage and metastatic forms of the disease. The mechanisms and molecular markers for prostate cancer metastasis are not fully understood. Speckle type Poz Protein (SPOP) is an E3 ubiquitin ligase adaptor that is often mutated in prostate cancer. In this study, we sequenced the

Indexed as

ITCHmetastasisprostate cancerSPOPubiquitylation

Identifiers

PMID34322378
PMCPMC8311740
OpenAlexW3179688850

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.