SynthesisImmunity, inflammation and disease2021
The clinical outcomes of COVID-19 in HIV-positive patients: A systematic review of current evidence.
Synthesis in Immunity, inflammation and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 8 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Hearing loss and COVID-19: an umbrella review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Pooled it
- Does telehealth affect the adherence to ART among patients with HIV? A systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- The impacts of COVID-19 pandemic on service delivery and treatment outcomes in people living with HIV: a systematic review.AIDS research and therapy · 2023Pooled it
- Public acceptability of COVID-19 vaccines and its predictors in Middle Eastern/North African (MENA) countries: a systematic review.Human vaccines & immunotherapeutics · 2022Pooled it
- COVID-19 in HIV-positive patients: A systematic review of case reports and case series.Journal of clinical laboratory analysis · 2022Pooled it
- Outcomes of patients with HIV and COVID-19 co-infection: a systematic review and meta-analysis.AIDS research and therapy · 2022Pooled it
- The clinical outcomes of COVID-19 in HIV-positive patients: A systematic review of current evidence.Immunity, inflammation and disease · 2021Pooled it
- The effects of hyperbaric oxygen therapy (HBOT) on coronavirus disease-2019 (COVID-19): a systematic review.European journal of medical research · 2021Pooled it
- Developing an app-based self-management program for people living with HIV: a randomized controlled pilot study during the COVID-19 pandemic.Scientific reports · 2022Trial
- Impact of COVID-19 on TB and HIV/AIDS severity in low- and middle-income countries: a systematic review.Dialogues in health · 2026Review
- High risk of COVID-19 mortality in people living with advanced HIV disease in South Africa: A retrospective cohort study.Medicine · 2026Article
- Exploring the Relationship Between Comorbidities and Prolonged Viral Shedding in COVID-19: A Cycle Threshold Value-Based Investigation.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026Article
- Aberrant innate immune profile associated with COVID-19 mortality in Pretoria, South Africa.Clinical immunology (Orlando, Fla.) · 2024Article
- People living with HIV with the Omicron variant infection have milder COVID-19 symptoms: results from a cross-sectional study.AIDS research and therapy · 2024Article
- Assessing COVID-19 Vulnerability Among HIV-positive Men Who Have Sex With Men in Korea: The Role of Vaccination and Sexual Behaviors.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2024Article
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- COVID-19 and HIV: Clinical Outcomes among Hospitalized Patients in the United States.Biomedicines · 2023Article
- Double Trouble Co-Infections: Understanding the Correlation Between COVID-19 and HIV Viruses.Cureus · 2023Review
- A Systematic Review: Impact of SARS-CoV-2 Infection on Morbidity, Mortality, and Viral Suppression in Patients Living With HIV.SN comprehensive clinical medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 9 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPatients with chronic underlying diseases are more susceptible to coronavirus disease 2019 (COVID-19) complications. Recent studies showed people living with HIV (PLWH) are not at greater risk than the general population. Few studies have reviewed the impacts of COVID-19 on PLWH. The purpose of this systematic review was to investigate the impact of COVID-19 on patients infected with HIV.
methodsWe executed a systematic search using four databases of PubMed, Scopus, Science Direct, and Web of Science and screened the records in two steps based on their title/abstract and full text. This study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist to elevate the validity and reliability of its results.
resultsWe reviewed 36 studies. The patients' age was above 20 years in all studies. In almost all studies, the inflammatory parameters were reported high. In most of the studies, all HIV patients completely recovered from the COVID 19 infection. Although CD4 count was not recorded in all studies, the minimum level was reported as 12 cells/µl.
conclusionBased on the current review, we concluded that HIV patients at advanced stages (3 or 4) of the disease, whose CD4 counts are low, may show less severe COVID-19 infection symptoms. Similarly, Interference can reduce the severity of immune reactions and subsequent cytokine storms and consequently mitigate the symptoms. Therefore, in most of the studies, the majority of HIV patients showed no severe symptoms and completely recovered from COVID 19 infection.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.