Evidence map›Paper›PMID 34324868›Full record

ReviewBiochemical pharmacology2021

Ocular surface complications in diabetes: The interrelationship between insulin and enkephalin.

Indira Purushothaman, Ian S Zagon, Joseph W Sassani, Patricia J McLaughlin

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Elevated Opioid Growth Factor Alters the Limbus in Type 1 Diabetic Rats.Journal of diabetes and clinical research · 2023
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Indira PurushothamanDepartment of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA.
Ian S ZagonDepartment of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA.
Joseph W SassaniDepartment of Ophthalmology, Penn State University College of Medicine, Hershey, PA 17033, USA.
Patricia J McLaughlinDepartment of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA. Electronic address: pxm9@psu.edu.
Pennsylvania State University · US

Funding

OGF-OGFr Axis Modulation to Prevent Diabetic Ocular Surface Complications.R01EY029223 · NEI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ZAGON, IAN S · 2018 to 2021
$1.5M
NEI NIH HHS R01 EY029223
6 · The paper itself

Abstract

Diabetes is a multi-faceted disorder with increasing prevalence and rising healthcare costs. The burden of diabetes is increased because of associated complications affecting nearly all organs including the eye. The underlying pathophysiology for the onset of these ocular surface disorders is not well known. Enkephalins are endogenous opioids that originate in the brain and have numerous actions in the human body. Opioid growth factor (OGF), chemically termed [Met

Indexed as

AnimalsCorneal DiseasesDiabetes ComplicationsDiabetes MellitusDry Eye SyndromesEnkephalinsHumansInsulinNaltrexoneNarcotic AntagonistsReceptors, OpioidEnkephalinsInsulinmethionine-enkephalin receptorNaltrexoneNarcotic AntagonistsReceptors, OpioidDiabetic keratopathyDry eyeInsulin[Met(5)]-enkephalinNaltrexoneOpioid growth factor

Identifiers

PMID34324868
PMCPMC8478878
OpenAlexW3185183378

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.