Evidence map›Paper›PMID 34328202›Full record

ArticleMolecular medicine reports2021

Urantide prevents CCl4‑induced acute liver injury in rats by regulating the MAPK signalling pathway.

Ying Li, Zheming Guo, Haipeng Cui, Tu Wang, Yuhang Xu, Juan Zhao

Open access · hybridAbstract read
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Improvement effect of Biluochun tea active extract on CClFood science and biotechnology · 2025
    Article
  4. Article
  5. Heliyon · 2024
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ying LiDepartment of Pathophysiology, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Zheming GuoSecond Department of Trauma, Third Hospital of Shijiazhuang City, Shijiazhuang, Hebei 050000, P.R. China.
Haipeng CuiDepartment of Pathophysiology, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Tu WangDepartment of Pathophysiology, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Yuhang XuDepartment of Pathophysiology, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Juan ZhaoDepartment of Pathophysiology, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Chengde Medical University · CNFirst Hospital of Shijiazhuang · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A number of drugs and other triggers can cause acute liver injury (ALI) in clinical practice. Therefore, identifying a safe drug for the prevention of liver injury is important. The aim of the present study was to investigate the potential preventive effect and regulatory mechanism of urantide on carbon tetrachloride (CCl

Indexed as

ActinsAnimalsCarbon TetrachlorideChemical and Drug Induced Liver InjuryDisease Models, AnimalExtracellular Signal-Regulated MAP KinasesMaleMAP Kinase Kinase 4MAP Kinase Signaling SystemOsteopontinp38 Mitogen-Activated Protein KinasesPeptide FragmentsRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledUrotensinsActa2 protein, ratActinsCarbon TetrachlorideExtracellular Signal-Regulated MAP KinasesMAP Kinase Kinase 4Osteopontinp38 Mitogen-Activated Protein KinasesPeptide FragmentsReceptors, G-Protein-CoupledSpp1 protein, raturotensin II (4-11), Pen(5)-Trp(7)-Orn(8)-UrotensinsUts2r protein, ratacute liver injuryMAPK signalling pathwayurantideurotensin II/urotensin receptor system

Identifiers

PMID34328202
PMCPMC8365596
OpenAlexW3185070380

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.