Evidence map›Paper›PMID 34334108›Full record

ArticleBioengineered2021

Nucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma.

Gang Wang, Fangfang Qu, Shouyong Liu, Jincai Zhou, Yi Wang

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  3. The role of m5C, m1A and m7G modifications in tumors of urinary system.Frontiers in cell and developmental biology · 2025
    Review
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  7. Function of mCancer biology & therapy · 2023
    Article
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  18. Upregulated expression of NOP2 predicts worse prognosis of gastric adenocarcinoma by promoting tumor growth.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gang WangDepartment of Urology, The Affiliated Jianhu Hospital of Nantong University, Jiangsu Province, China.
Fangfang QuDepartment of Anesthesiology, The Affiliated Jianhu Hospital of Nantong University, Jiangsu Province, China.
Shouyong LiuDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Jincai ZhouDepartment of Urology, The Affiliated Jianhu Hospital of Nantong University, Jiangsu Province, China.
Yi WangDepartment of Urology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.ORCID 0000-0002-2067-5465
Nantong University · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As an indispensable part for cancer precision medicine, biomarkers and signatures for predicting cancer prognosis and therapeutic benefits were urgently required. The purpose of this study was to investigate the prognostic roles of NOP2 in renal clear cell carcinoma (ccRCC) for overall survival (OS) and its relationships with immunity. NOP2-related gene expression matrix associated with clinical information was obtained from the Cancer Genome Atlas (TCGA) ccRCC dataset and NOP2-related pathways were identified by gene set enrichment analysis (GSEA). Associations among the NOP2 expression and MSI, TMB, TNB, and immunity were also explored. Both the NOP2 mRNA and protein/phosphoprotein had a higher expression in ccRCC tumor tissues than in normal kidney tissues (both

Indexed as

Carcinoma, Renal CellKidney NeoplasmsBiomarkers, TumorHumansKidneyNuclear ProteinsPrognosisSignal TransductionTranscriptometRNA MethyltransferasesBiomarkers, TumorNOP2 protein, humanNuclear ProteinstRNA Methyltransferasesclear cell renal cell carcinomaNOP2prognosisTCGA

Identifiers

PMID34334108
PMCPMC8806646
OpenAlexW3188850127

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.