ReviewDisease markers2021
Ischemia-Modified Albumin: Origins and Clinical Implications.
Review in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 4 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Systematic review and meta-analysis of stroke blood biomarker data highlights need for more translational research methods.Nature communications · 2026Pooled it
- Ischemia-modified albumin in rheumatic diseases: A systematic review and meta-analysis.Immunity, inflammation and disease · 2024Pooled it
- The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis.Biology of sex differences · 2022Pooled it
- Pooled it
- Perioperative Hyperoxia and Early Pulmonary Epithelial and Glycocalyx-Related Biomarker Trajectories in Laparoscopic Surgery: A Prospective Randomized Study.Life (Basel, Switzerland) · 2026Article
- Oxidative Stress Biomarkers in Cerebral Palsy: Ischemia-Modified Albumin, Protein Carbonyl Compounds, AOPP, and Functional Status.Journal of clinical practice and research · 2026Article
- Comparison of Albumin and Ischemia-Modified Albumin Levels in Concurrent Blood and Cerebrospinal Fluid in Patients with Spontaneous Subarachnoid Hemorrhage and Normal Pressure Hydrocephalus.Medicina (Kaunas, Lithuania) · 2026Article
- Colorimetric Detection of Arsenic (III) and Mercury (II) Ions in Human Serum Albumin Samples Using Cysteine-Capped Gold Nanoparticles.Sensors (Basel, Switzerland) · 2026Article
- Oxidants, antioxidants, and the clinical course of COVID-19 disease: a prospective observational study.Virology journal · 2026Observational
- Altered serum biomarkers of oxidative stress and antioxidant capacity in primary open-angle glaucoma.Scientific reports · 2026Article
- Advances in biomarkers for myocardial injury after non-cardiac surgery.Journal of anesthesia and translational medicine · 2026Review
- Effects of major solid cancer surgery on oxidative stress assessed by plasma xanthine oxidase and adenosine deaminase activity : a pilot study.World journal of surgical oncology · 2026Article
- Cord blood cardiac markers and tissue doppler echocardiography findings in infants of diabetic mothers.Italian journal of pediatrics · 2026Article
- Ischemia-modified albumin in children with clinically suspected acute myocarditis: diagnostic performance and incremental value beyond conventional biomarkers.Frontiers in pediatrics · 2026Article
- Oxidative stress markers in bipolar disorder and first-degree relatives: differential associations of ischemia-modified albumin and superoxide dismutase.Frontiers in psychiatry · 2026Article
- The Level of Ischemia-Modified Albumin in Healthy Individuals of Different Age Groups.Bulletin of experimental biology and medicine · 2025Article
- The Role of High-Sensitivity Cardiac Troponin and Ischemia-Modified Albumin in Patients with Lower Extremity Peripheral Arterial Disease.International journal of molecular sciences · 2025Review
- Can Oxidative Stress Biomarkers Differentiate Trichotillomania from Obsessive-Compulsive Disorder and Healthy Controls?Journal of molecular neuroscience : MN · 2025Article
- The Predictive Role of Thiol/Disulfide Homeostasis as an Oxidative Stress Parameter in Sarcopenic Obesity.Medicina (Kaunas, Lithuania) · 2025Article
- Recurrent aphthous stomatitis, oxidative stress, and ischemia modified albumin: A cross-sectional study.Medicine · 2025Observational
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Albumin is one of the most abundant proteins in the body of mammals: about 40% of its pool is located in the intravascular space and the remainder is found in the interstitial space. The content of this multifunctional protein in blood is about 60-65% of total plasma proteins. A decrease in its synthesis or changes of functional activity can destabilize oncotic blood pressure, cause a violation of transporting hormones, fatty acids, metals, and drugs. Albumin properties change under ischemic attacks associated with oxidative stress, production of reactive oxygen species, and acidosis. Under these conditions, ischemia-modified albumin (IMA) is generated that has a reduced metal-binding capacity, especially for transition metals, such as copper, nickel, and cobalt. The method of determining the cobalt-binding capability of HSA was initially proposed to evaluate IMA level and then licensed as an ACB test for routine clinical analysis for myocardial ischemia. Subsequent studies have shown the viability of the ACB test in diagnosing other diseases associated with the development of oxidative stress. This review examines recent data on IMA generation mechanisms, describes principles, advantages, and limitations of methods for evaluation of IMA levels, and provides detailed analysis of its use in diagnostic and monitoring therapeutic efficacy in different diseases.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.