Evidence map›Paper›PMID 34337600›Full record

ArticleJournal of cellular immunology2021

Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic.

Kae Myriam Pusic, Lisa Won, Richard Paul Kraig, Aya Darinka Pusic

Open access · goldAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of cellular immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kae Myriam PusicDepartment of Neurology, The University of Chicago, Chicago, Il 60637-1470, USA.
Lisa WonDepartment of Neurology, The University of Chicago, Chicago, Il 60637-1470, USA.
Richard Paul KraigDepartment of Neurology, The University of Chicago, Chicago, Il 60637-1470, USA.
Aya Darinka PusicDepartment of Neurology, The University of Chicago, Chicago, Il 60637-1470, USA.
University of Chicago · US

Funding

The Institute for Translational MedicineUL1TR002389 · NCATS · UNIVERSITY OF CHICAGO · PI Joshua J Jacobs, DAVID O MELTZER · 2017 to 2026
$71.6M
Institutional Career Development Core (Chapter 1)KL2TR002387 · NCATS · UNIVERSITY OF CHICAGO · PI ERIC C BEYER, Lisa L Barnes · 2017 to 2026
$7.6M
HYDROGEN IONS AND BRAIN INFARCTIONR01NS019108 · NINDS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI KRAIG, RICHARD P · 1985 to 2019
$5.2M
Exosome RNA-Therapeutics to Promote CNS MyelinationUH3TR000918 · NCATS · UNIVERSITY OF CHICAGO · PI KRAIG, RICHARD P · 2015 to 2017
$1.1M
Exosome RNA-Therapeutics to Promote CNS MyelinationUH2TR000918 · NCATS · UNIVERSITY OF CHICAGO · PI KRAIG, RICHARD P · 2013 to 2014
$568k
NCATS NIH HHS KL2 TR002387NCATS NIH HHS UH2 TR000918NCATS NIH HHS UH3 TR000918NCATS NIH HHS UL1 TR002389NINDS NIH HHS R01 NS019108
6 · The paper itself

Abstract

Environmental enrichment produces beneficial effects in the brain at genetic, molecular, cellular and behavior levels, and has long been studied as a therapeutic intervention for a wide variety of neurological disorders. However, the complexity of applying a robust environmental enrichment paradigm makes clinical use difficult. Accordingly, there has been increased interest in developing environmental enrichment mimetics, also known as enviromimetics. Here we review the benefits of environmental enrichment for migraine treatment, and discuss the potential of using extracellular vesicles derived from interferon gamma-stimulated dendritic cells as an effective mimetic.

Indexed as

EnviromimeticsEnvironmental enrichmentExosomesExtracellular vesiclesInterferon gammaMigraineOxidative stressSpreading depression

Identifiers

PMID34337600
PMCPMC8321388
OpenAlexW3184851018

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.