Evidence map›Paper›PMID 34345845›Full record

ArticleCurrent research in toxicology2020

The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettes.

Liam Simms, Kathryn Rudd, Jessica Palmer, Lukasz Czekala, Fan Yu, Fiona Chapman, Edgar Trelles Sticken, Roman Wieczorek, Lisa Maria Bode, Matthew Stevenson and 1 more

Open access · goldAbstract read
In one paragraph

Article in Current research in toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Human Primary Mesenchymal Stem Cells Fail to Recover Full Osteogenic Differentiation Potential Following Washout of Electronic Cigarette Aerosol Extracts.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Optimisation of anFrontiers in toxicology · 2024
    Article
  8. Article
  9. Prospecting forJournal of biomolecular structure & dynamics · 2022
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Liam SimmsImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, UK.
Kathryn RuddImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, UK.
Jessica PalmerStemina Biomarker Discovery Inc., 504 S. Rosa Rd., Madison, WI 53719, USA.
Lukasz CzekalaImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, UK.
Fan YuImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, UK.
Fiona ChapmanImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, UK.
Edgar Trelles StickenReemtsma Cigarettenfabriken GmbH, An Imperial Brands PLC Company, Albert-EinsteinRing-7, D-22761 Hamburg, Germany.
Roman WieczorekReemtsma Cigarettenfabriken GmbH, An Imperial Brands PLC Company, Albert-EinsteinRing-7, D-22761 Hamburg, Germany.
Lisa Maria BodeReemtsma Cigarettenfabriken GmbH, An Imperial Brands PLC Company, Albert-EinsteinRing-7, D-22761 Hamburg, Germany.
Matthew StevensonImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, UK.
Tanvir WaleleImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, UK.
Imperial Brands (United Kingdom) · GBBritish American Tobacco (Germany) · DEStemina Biomarker Discovery (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

devTOX

Indexed as

ATRA, All-trans-retinoic acidbPBS, bubbled phosphate buffered salineCDC, Centers for Disease Control and PreventionCigarettesCOT, United Kingdom Committee on Toxicity of Chemicals in Food, Consumer Products and the EnvironmentCV, coefficient of variationDART, developmental and reproductive toxicityDevelopmental toxicitydevTOXqP, devTOX quickPredictDNPH, 2,4-dinitrophenylhydrazinedTP, developmental toxicity potential concentrationdTT, developmental toxicity thresholdE-cigarettese-cigarettes, electronic cigarettesECVAM, European Center for the Validation of Alternative MethodsEPA, United States Environmental Protection AgencyEVP, electronic vapour productFDR, false discovery rateHPHCs, Harmful and Potentially Harmful ConstituentsHPLC-DAD, high-performance liquid chromatography with a diode-array detectorHTP, heated tobacco productHuman induced pluripotent stem cellsHYB, hybrid productIn vitro reproduction assayiPS cells, induced pluripotent stem cellsISO, International Organization for StandardisationISTD, internal standardLC-MS/MS, liquid chromatography with tandem mass spectrometryLOQ, limit of quantificationnAChRs, nicotinic acetylcholine receptorsND, No effect was detected within the exposure range testedNHS, United Kingdom National Health ServiceNICE, National Institute for Health and Care ExcellenceNicotineo/c, ornithine/cystine ratioODC, ornithine decarboxylaseOECD, Organisation for Economic Co-operation and DevelopmentPBS, phosphate buffered salinePG/VG, propylene glycol/vegetable glycerinePOD, point of differenceQ-TOF, Quadrupole Time-of-FlightROS, reactive oxygen speciesTP, cell viability toxicity potential concentrationTT21C, toxicity testing in the 21st centuryUPLC-HRMS, ultra-high performance liquid chromatography coupled high resolution mass spectrometry

Identifiers

PMID34345845
PMCPMC8320631
OpenAlexW3103079897

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.