Evidence map›Paper›PMID 34346292›Full record

ArticleRNA biology2021

Annexin A2 binds the internal ribosomal entry site of c-

Elin Strand, Hanne Hollås, Siri Aastedatter Sakya, Sofya Romanyuk, Mikko E V Saraste, Ann Kari Grindheim, Sudarshan S Patil, Anni Vedeler

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Annexin, a Protein for All Seasons: From Calcium Dependent Membrane Metabolism to RNA Recognition.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  4. Article
  5. Review
  6. RNA-binding is an ancient trait of the Annexin family.Frontiers in cell and developmental biology · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Elin StrandDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Hanne HollåsDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Siri Aastedatter SakyaDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Sofya RomanyukDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Mikko E V SarasteDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Ann Kari GrindheimDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Sudarshan S PatilDepartment of Biomedicine, University of Bergen, Bergen, Norway.ORCID 0000-0002-6294-7959
Anni VedelerDepartment of Biomedicine, University of Bergen, Bergen, Norway.ORCID 0000-0003-0347-8918
University of Bergen · NOCity Hospital No. 40 · RUHaukeland University Hospital · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression and localization of the oncoprotein c-Myc is highly regulated at the level of transcription, mRNA transport, translation, as well as stability of the protein. We previously showed that Annexin A2 (AnxA2) binds to a specific localization element in the 3'untranslated region (UTR) of c-

Indexed as

Internal Ribosome Entry SitesProtein Biosynthesis5' Untranslated RegionsAnnexin A2Binding SitesHumansProtein BindingProto-Oncogene Proteins c-mycRNA, Messenger5' Untranslated RegionsAnnexin A2ANXA2 protein, humanInternal Ribosome Entry SitesMYC protein, humanProto-Oncogene Proteins c-mycRNA, MessengerAnnexin A2calciumc-MycforskolinIRESITAFStranslation

Identifiers

PMID34346292
PMCPMC8677036
OpenAlexW3188714540

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.