Evidence map›Paper›PMID 34349016›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.

Hiroo Takahashi, Ryo Asahina, Masayuki Fujioka, Takeshi K Matsui, Shigeki Kato, Eiichiro Mori, Hiroyuki Hioki, Tohru Yamamoto, Kazuto Kobayashi, Akio Tsuboi

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Recent Advances in Molecular Research on Hydrogen Sulfide (HInternational journal of molecular sciences · 2022
    Pooled it
  3. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hiroo TakahashiDepartment of Molecular Neurobiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan; t.akiorex@gmail.com htakahas@med.kagawa-u.ac.jp.ORCID 0000-0003-2425-3451
Ryo AsahinaLaboratory for Molecular Biology of Neural Systems, Advanced Medical Research Center, Nara Medical University, Nara 634-8521, Japan.
Masayuki FujiokaLaboratory for Molecular Biology of Neural Systems, Advanced Medical Research Center, Nara Medical University, Nara 634-8521, Japan.
Takeshi K MatsuiDepartment of Future Basic Medicine, School of Medicine, Nara Medical University, Nara 634-8521, Japan.
Shigeki KatoDepartment of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Fukushima 960-1295, Japan.ORCID 0000-0002-8792-7591
Eiichiro MoriDepartment of Future Basic Medicine, School of Medicine, Nara Medical University, Nara 634-8521, Japan.ORCID 0000-0003-0945-196X
Hiroyuki HiokiDepartment of Cell Biology and Neuroscience, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.ORCID 0000-0002-0152-7854
Tohru YamamotoDepartment of Molecular Neurobiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.ORCID 0000-0002-1652-0233
Kazuto KobayashiDepartment of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Fukushima 960-1295, Japan.ORCID 0000-0002-7617-2939
Akio TsuboiLaboratory for Molecular Biology of Neural Systems, Advanced Medical Research Center, Nara Medical University, Nara 634-8521, Japan; t.akiorex@gmail.com htakahas@med.kagawa-u.ac.jp.
Nara Medical University · JPFukushima Medical University · JPKagawa University · JPJuntendo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke, which results in loss of neurological function, initiates a complex cascade of pathological events in the brain, largely driven by excitotoxic Ca

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCalciumCalcium Channels, L-TypeCell DeathHEK293 CellsHumansInfarction, Middle Cerebral ArteryIschemic StrokeMaleMiceMice, Inbred C57BLMice, KnockoutMonomeric GTP-Binding ProteinsNeuronsOrganoidsBasic Helix-Loop-Helix ProteinsCalciumCalcium Channels, L-TypeGEM protein, humanGem protein, mouseMonomeric GTP-Binding ProteinsNpas4 protein, mouseischemic strokeneural activity–dependentneuroplasticityneuroprotectionNpas4

Identifiers

PMID34349016
PMCPMC8364162
OpenAlexW3189987462

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.