Evidence map›Paper›PMID 34356104›Full record

ArticleGenes2021

Analysis of a Set of KDM5C Regulatory Genes Mutated in Neurodevelopmental Disorders Identifies Temporal Coexpression Brain Signatures.

Loredana Poeta, Agnese Padula, Maria Brigida Lioi, Hans van Bokhoven, Maria Giuseppina Miano

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Identification of Novel Co-OccurringThe application of clinical genetics · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. The Chromatin-Oxygen Sensor GeneInternational journal of molecular sciences · 2022
    Article
  15. Article
  16. Further Delineation of Duplications ofInternational journal of molecular sciences · 2022
    Review
  17. Astroglia in Autism Spectrum Disorder.International journal of molecular sciences · 2021
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Loredana PoetaInstitute of Genetics and Biophysics Adriano Buzzati-Traverso, CNR, 80131 Naples, Italy.ORCID 0000-0001-7272-1040
Agnese PadulaInstitute of Genetics and Biophysics Adriano Buzzati-Traverso, CNR, 80131 Naples, Italy.
Maria Brigida LioiDepartment of Science, University of Basilicata, 85100 Potenza, Italy.
Hans van BokhovenDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboudumc, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-2153-9254
Maria Giuseppina MianoInstitute of Genetics and Biophysics Adriano Buzzati-Traverso, CNR, 80131 Naples, Italy.ORCID 0000-0003-1396-9673
Institute of Genetics and Biophysics · ITUniversity of Basilicata · ITRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulation of transcriptional pathways is observed in multiple forms of neurodevelopmental disorders (NDDs), such as intellectual disability (ID), epilepsy and autism spectrum disorder (ASD). We previously demonstrated that the NDD genes encoding lysine-specific demethylase 5C (

Indexed as

AnimalsAutism Spectrum DisorderCell Line, TumorDNA-Binding ProteinsEpilepsyGene ExpressionGene Expression RegulationGenes, HomeoboxGenes, X-LinkedHistone DemethylasesHistonesHomeodomain ProteinsHumansIntellectual DisabilityMethylationMiceARX protein, humanDNA-Binding ProteinsHistone Demethylaseshistone H3 trimethyl Lys4HistonesHomeodomain ProteinsKDM5C protein, humanPHF8 protein, humanTranscription FactorsZNF711 protein, humandisease mutationsH3K4me3KDM5CNDD-related chromatinopathiesneurodevelopmental disordersX-chromosome

Identifiers

PMID34356104
PMCPMC8305412
OpenAlexW3185053674

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.