Evidence map›Paper›PMID 34356314›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Integration of Cardiac Actin Mutants Causing Hypertrophic (p.A295S) and Dilated Cardiomyopathy (p.R312H and p.E361G) into Cellular Structures.

Constanze Erdmann, Roua Hassoun, Sebastian Schmitt, Carlos Kikuti, Anne Houdusse, Antonina J Mazur, Andreas Mügge, Nazha Hamdani, Matthias Geyer, Kornelia Jaquet and 1 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Hypertrophic cardiomyopathy: insights into pathophysiology and novel therapeutic strategies from clinical studies.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Cardiomyocyte Dysfunction in Inherited Cardiomyopathies.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Constanze ErdmannDepartment of Anatomy and Molecular Embryology, Medical Faculty, Ruhr-University Bochum, D-44780 Bochum, Germany.
Roua HassounInstitut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, D-44780 Bochum, Germany.
Sebastian SchmittInstitute of Structural Biology, University of Bonn, D-53127 Bonn, Germany.
Carlos KikutiInstitut Curie, Structural Motility Team, F-75005 Paris, France.ORCID 0000-0001-5928-2776
Anne HoudusseInstitut Curie, Structural Motility Team, F-75005 Paris, France.
Antonina J MazurDepartment of Cell Pathology, Faculty of Biotechnology, University of Wroclaw, Pl-50-383 Wroclaw, Poland.ORCID 0000-0002-7561-9030
Andreas MüggeInstitut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, D-44780 Bochum, Germany.
Nazha HamdaniInstitut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, D-44780 Bochum, Germany.
Matthias GeyerInstitute of Structural Biology, University of Bonn, D-53127 Bonn, Germany.ORCID 0000-0002-7718-5002
Kornelia JaquetInstitut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, D-44780 Bochum, Germany.
Hans Georg MannherzDepartment of Anatomy and Molecular Embryology, Medical Faculty, Ruhr-University Bochum, D-44780 Bochum, Germany.
St. Josef-Hospital · DEInstitut Curie · FRUniversity of Bonn · DERuhr University Bochum · DEUniversity of Wrocław · PL

Funding

The Deutsche Forschungsgemeinschaft (DFG) MA 807/19-1; HA7512/2-1; and HA 7512/2-4
6 · The paper itself

Abstract

The human mutant cardiac α-actins p.A295S or p.R312H and p.E361G, correlated with hypertrophic or dilated cardiomyopathy, respectively, were expressed by the

Indexed as

Arp2/3 complexATPasecardiac actincardiomyopathiesMICAL

Identifiers

PMID34356314
PMCPMC8301065
OpenAlexW3179439373

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.