Evidence map›Paper›PMID 34356525›Full record

ArticleBiology2021

PI3K as Mediator of Apoptosis and Contractile Dysfunction in TGFβ

Paulin Brosinsky, Julia Bornbaum, Björn Warga, Lisa Schulz, Klaus-Dieter Schlüter, Alessandra Ghigo, Emilio Hirsch, Rainer Schulz, Gerhild Euler, Jacqueline Heger

Open access · goldAbstract read
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Paulin BrosinskyInstitute of Physiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.
Julia BornbaumInstitute of Physiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.
Björn WargaInstitute of Physiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.
Lisa SchulzInstitute of Physiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.
Klaus-Dieter SchlüterInstitute of Physiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.ORCID 0000-0002-6093-4919
Alessandra GhigoDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.ORCID 0000-0002-1193-5296
Emilio HirschDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.ORCID 0000-0002-9073-6024
Rainer SchulzInstitute of Physiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.ORCID 0000-0003-3017-0476
Gerhild EulerInstitute of Physiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.ORCID 0000-0001-9094-773X
Jacqueline HegerInstitute of Physiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.
Justus-Liebig-Universität Gießen · DEUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTGFβ METHODS AND

resultsIncubation of isolated ventricular cardiomyocytes with TGFβ

conclusionsTGFβ

Indexed as

ALK5apoptosiscardiomyocytescontractile functionPI3KSMADTGFβ1

Identifiers

PMID34356525
PMCPMC8301398
OpenAlexW3180900974

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.