Evidence map›Paper›PMID 34359733›Full record

ArticleCancers2021

Neonatal Nav1.5 Protein Expression in Human Colorectal Cancer: Immunohistochemical Characterization and Clinical Evaluation.

Elena Lastraioli, Scott P Fraser, R Mine Guzel, Jessica Iorio, Lapo Bencini, Emanuela Scarpi, Luca Messerini, Vincenzo Villanacci, Giulia Cerino, Niccolo' Ghezzi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Effects of NaCell biochemistry and biophysics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Elena LastraioliDepartment of Experimental and Clinical Medicine, University of Florence, viale GB Morgagni 50, 50134 Florence, Italy.ORCID 0000-0002-1531-8973
Scott P FraserDepartment of Life Sciences, South Kensington Campus, Imperial College London, London SW7 2AZ, UK.
R Mine GuzelDepartment of Life Sciences, South Kensington Campus, Imperial College London, London SW7 2AZ, UK.
Jessica IorioDepartment of Experimental and Clinical Medicine, University of Florence, viale GB Morgagni 50, 50134 Florence, Italy.
Lapo BenciniDepartment of Oncology, Division of Oncologic Surgery and Robotics, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134 Florence, Italy.
Emanuela ScarpiUnit of Biostatistics and Clinical Trials, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Via P Maroncelli 40, 47014 Meldola, Italy.ORCID 0000-0001-7230-9267
Luca MesseriniDepartment of Experimental and Clinical Medicine, University of Florence, viale GB Morgagni 50, 50134 Florence, Italy.
Vincenzo VillanacciInstitute of Pathology, ASST Spedali Civili di Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy.
Giulia CerinoDepartment of Oncology, Division of Oncologic Surgery and Robotics, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134 Florence, Italy.
Niccolo' GhezziDepartment of Oncology, Division of Oncologic Surgery and Robotics, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134 Florence, Italy.
Giuseppe PerronePathology Unit, Campus Bio-Medico University, via A del Portillo 200, 00128 Rome, Italy.
Mustafa B A DjamgozDepartment of Life Sciences, South Kensington Campus, Imperial College London, London SW7 2AZ, UK.
Annarosa ArcangeliDepartment of Experimental and Clinical Medicine, University of Florence, viale GB Morgagni 50, 50134 Florence, Italy.
University of Florence · ITAzienda Ospedaliero-Universitaria Careggi · ITImperial College London · GBAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITCyprus International University · CYIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITUniversità Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Voltage-gated Na

Indexed as

colorectal cancerimmunohistochemistrymetastasisneonatal Nav1.5voltage-gated sodium channel

Identifiers

PMID34359733
PMCPMC8345135
OpenAlexW3183854614

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.