Evidence map›Paper›PMID 34360437›Full record

ArticleInternational journal of environmental research and public health2021

Anxiety Levels Predict Bone Mineral Density in Postmenopausal Women Undergoing Oral Bisphosphonates: A Two-Year Follow-Up.

Gabriella Martino, Federica Bellone, Carmelo M Vicario, Agostino Gaudio, Andrea Caputo, Francesco Corica, Giovanni Squadrito, Peter Schwarz, Nunziata Morabito, Antonino Catalano

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Gabriella MartinoDepartment of Clinical and Experimental Medicine, University Hospital of Messina, 98122 Messina, Italy.ORCID 0000-0001-9488-2021
Federica BelloneDepartment of Clinical and Experimental Medicine, University Hospital of Messina, 98122 Messina, Italy.ORCID 0000-0002-0467-4921
Carmelo M VicarioDepartment of Cognitive Sciences, Psychology, Education and Cultural Studies, University of Messina, 98121 Messina, Italy.
Agostino GaudioDepartment of Clinical and Experimental Medicine, University Hospital of Catania, 95123 Catania, Italy.ORCID 0000-0002-9958-9606
Andrea CaputoDepartment of Dynamic and Clinical Psychology and Health Studies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-3516-8332
Francesco CoricaDepartment of Clinical and Experimental Medicine, University Hospital of Messina, 98122 Messina, Italy.ORCID 0000-0001-8253-5057
Giovanni SquadritoDepartment of Clinical and Experimental Medicine, University Hospital of Messina, 98122 Messina, Italy.
Peter SchwarzDepartment of Endocrinology, Research Centre for Ageing and Osteoporosis, Rigshospitalet-Glostrup Hospital, 2100 Copenhagen, Denmark.ORCID 0000-0002-0483-8594
Nunziata MorabitoDepartment of Clinical and Experimental Medicine, University Hospital of Messina, 98122 Messina, Italy.
Antonino CatalanoDepartment of Clinical and Experimental Medicine, University Hospital of Messina, 98122 Messina, Italy.ORCID 0000-0003-3890-2299
University of Messina · ITGlostrup Hospital · DKSapienza University of Rome · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical psychological factors may predict medical diseases. Anxiety level has been associated with osteoporosis, but its role on bone mineral density (BMD) change is still unknown. This study aimed to investigate the association between anxiety levels and both adherence and treatment response to oral bisphosphonates (BPs) in postmenopausal osteoporosis. BMD and anxiety levels were evaluated trough dual-energy X-ray absorptiometry and the Hamilton Anxiety Rating Scale (HAM-A), respectively. Participants received weekly medication with alendronate or risedronate and were grouped according to the HAM-A scores into tertiles (HAM-A 3 > HAM-A 2 > HAM-A 1). After 24 months, BMD changes were different among the HAM-A tertiles. The median lumbar BMD change was significantly greater in both the HAM-A 2 and HAM-A 3 in comparison with the HAM-A 1. The same trend was observed for femoral BMD change. Adherence to BPs was >75% in 68% of patients in the HAM-A 1, 79% of patients in the HAM-A 2, and 89% of patients in the HAM-A 3 (

Indexed as

Bone DensityOsteoporosis, PostmenopausalAnxietyFemaleFollow-Up StudiesHumansLumbar VertebraePostmenopauseRisedronic AcidRisedronic Acidadherencealendronateanxietybisphosphonatesbone mineral densityclinical psychologyfracture riskosteoporosispostmenopausal womenrisedronate

Identifiers

PMID34360437
PMCPMC8346074
OpenAlexW3190163084

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.