Evidence map›Paper›PMID 34360548›Full record

ArticleInternational journal of molecular sciences2021

Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes.

Catharina M Alam, Sarah Baghestani, Ada Pajari, M Bishr Omary, Diana M Toivola

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Primaquine activates Keratin 7 to treat diabetes and its complications.Journal of diabetes and metabolic disorders · 2022
    Article
  6. Recent Advances in Intermediate Filaments-Volume 1.International journal of molecular sciences · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Catharina M AlamDepartment of Biosciences, Cell Biology, Åbo Akademi University, Tykistökatu 6A, BioCity 2nd Floor, FIN-20520 Turku, Finland.
Sarah BaghestaniDepartment of Biosciences, Cell Biology, Åbo Akademi University, Tykistökatu 6A, BioCity 2nd Floor, FIN-20520 Turku, Finland.
Ada PajariDepartment of Biosciences, Cell Biology, Åbo Akademi University, Tykistökatu 6A, BioCity 2nd Floor, FIN-20520 Turku, Finland.
M Bishr OmaryCenter for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0002-8624-2347
Diana M ToivolaDepartment of Biosciences, Cell Biology, Åbo Akademi University, Tykistökatu 6A, BioCity 2nd Floor, FIN-20520 Turku, Finland.ORCID 0000-0001-7165-9839
Åbo Akademi University · FIRutgers, The State University of New Jersey · US

Funding

Åbo Akademi University Center of Excellence in MechanostasisAcademy of Finland 332582Medicl Supportfoundation Liv och HälsaNovo Nordisk Fonden NNF17O0027254Novo Nordisk Fonden NNF20OC0063889Stiftelsen för Åbo AkademiSvenska Kulturfonden
6 · The paper itself

Abstract

Keratin (K) 7 is an intermediate filament protein expressed in ducts and glands of simple epithelial organs and in urothelial tissues. In the pancreas, K7 is expressed in exocrine ducts, and apico-laterally in acinar cells. Here, we report K7 expression with K8 and K18 in the endocrine islets of Langerhans in mice. K7 filament formation in islet and MIN6 β-cells is dependent on the presence and levels of K18. K18-knockout (K18

Indexed as

AnimalsDiabetes Mellitus, ExperimentalGene Expression RegulationInsulin-Secreting CellsKeratin-18Keratin-7Keratin-8MiceMice, KnockoutUp-RegulationKeratin-18Keratin-7Keratin-8beta-celldiabetesisletkeratinKrt7MIN6polaritystress

Identifiers

PMID34360548
PMCPMC8346022
OpenAlexW3186275145

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.