Evidence map›Paper›PMID 34360676›Full record

ReviewInternational journal of molecular sciences2021

Deep Learning with Neuroimaging and Genomics in Alzheimer's Disease.

Eugene Lin, Chieh-Hsin Lin, Hsien-Yuan Lane

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Temporal Analysis of Embryonic Epidermal Morphogenesis inInternational journal of molecular sciences · 2025
    Article
  6. Enabling Few-Shot Alzheimer's Disease Diagnosis on Biomarker Data with Tabular LLMs.ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Cardiovascular Disease and Alzheimer's Disease: The Heart-Brain Axis.Journal of the American Heart Association · 2023
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. From Menopause to Neurodegeneration-Molecular Basis and Potential Therapy.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eugene LinDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Chieh-Hsin LinGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Hsien-Yuan LaneGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0003-2162-8174

Funding

Chang Gung Memorial Hospital CMRPG8G1391, CMRPG8K1161, CMRPG8K1461China Medical University Hospital DMR-109-105; DMR-HHC-110-9Ministry of Science and Technology in Taiwan MOST 109-2628-B-182A-002; MOST 110-2314-B-182A-048National Health Research Institutes, Taiwan NHRI-EX110-10816NC
6 · The paper itself

Abstract

A growing body of evidence currently proposes that deep learning approaches can serve as an essential cornerstone for the diagnosis and prediction of Alzheimer's disease (AD). In light of the latest advancements in neuroimaging and genomics, numerous deep learning models are being exploited to distinguish AD from normal controls and/or to distinguish AD from mild cognitive impairment in recent research studies. In this review, we focus on the latest developments for AD prediction using deep learning techniques in cooperation with the principles of neuroimaging and genomics. First, we narrate various investigations that make use of deep learning algorithms to establish AD prediction using genomics or neuroimaging data. Particularly, we delineate relevant integrative neuroimaging genomics investigations that leverage deep learning methods to forecast AD on the basis of incorporating both neuroimaging and genomics data. Moreover, we outline the limitations as regards to the recent AD investigations of deep learning with neuroimaging and genomics. Finally, we depict a discussion of challenges and directions for future research. The main novelty of this work is that we summarize the major points of these investigations and scrutinize the similarities and differences among these investigations.

Indexed as

Deep LearningAlzheimer DiseaseBrainGenomicsHumansNeuroimagingAlzheimer’s diseaseartificial intelligencedeep learninggenomicsmachine learningmulti-omicsneuroimagingsingle nucleotide polymorphisms

Identifiers

PMID34360676
PMCPMC8347529

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.