Evidence map›Paper›PMID 34360683›Full record

ArticleInternational journal of molecular sciences2021

Syndecan Transmembrane Domain Specifically Regulates Downstream Signaling Events of the Transmembrane Receptor Cytoplasmic Domain.

Jisun Hwang, Bohee Jang, Ayoung Kim, Yejin Lee, Joonha Lee, Chungho Kim, Jinmahn Kim, Kyeong Min Moon, Kyuhyung Kim, Ram Wagle and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jisun HwangDepartment of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Bohee JangDepartment of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Ayoung KimDepartment of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Yejin LeeDepartment of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Joonha LeeDepartment of Life Sciences, Korea University, Seoul 02841, Korea.
Chungho KimDepartment of Life Sciences, Korea University, Seoul 02841, Korea.
Jinmahn KimDepartment of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
Kyeong Min MoonDepartment of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.ORCID 0000-0003-0368-5458
Kyuhyung KimDepartment of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
Ram WagleDepartment of Biomedical Gerontology, Ilsong Institute of Life Science, Hallym University, Anyang-si 14066, Korea.ORCID 0000-0002-1810-5930
Young-Han SongDepartment of Biomedical Gerontology, Ilsong Institute of Life Science, Hallym University, Anyang-si 14066, Korea.ORCID 0000-0002-0758-3654
Eok-Soo OhDepartment of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Ewha Womans University · KRDaegu Gyeongbuk Institute of Science and Technology · KRHallym University · KRKorea University · KR

Funding

National Research Foundation of Korea 2019R1A2C2009011
6 · The paper itself

Abstract

Despite the known importance of the transmembrane domain (TMD) of syndecan receptors in cell adhesion and signaling, the molecular basis for syndecan TMD function remains unknown. Using in vivo invertebrate models, we found that mammalian syndecan-2 rescued both the guidance defects in

Indexed as

Cell AdhesionProtein DomainsSignal TransductionAnimalsHEK293 CellsHumansMiceNIH 3T3 CellsPhosphatidylinositol 3-KinasesPhosphorylationProtein MultimerizationProtein Processing, Post-Translationalsrc-Family KinasesSyndecan-2Phosphatidylinositol 3-Kinasessrc-Family KinasesSyndecan-2PDGFRsignal transductionsyndecantransmembrane domain

Identifiers

PMID34360683
PMCPMC8347082
OpenAlexW3186283314

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.