Evidence map›Paper›PMID 34360767›Full record

ReviewInternational journal of molecular sciences2021

HTLV-1 Infection and Pathogenesis: New Insights from Cellular and Animal Models.

Greta Forlani, Mariam Shallak, Roberto Sergio Accolla, Maria Grazia Romanelli

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Association BetweenPathogens (Basel, Switzerland) · 2025
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Viral zoonosis and human cancer: a perspective.Infectious agents and cancer · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
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  18. Article
  19. Activation of theGenes · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Greta ForlaniLaboratory of General Pathology and Immunology "Giovanna Tosi", Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.ORCID 0000-0003-1987-7761
Mariam ShallakLaboratory of General Pathology and Immunology "Giovanna Tosi", Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.
Roberto Sergio AccollaLaboratory of General Pathology and Immunology "Giovanna Tosi", Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.
Maria Grazia RomanelliDepartment of Biosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-7360-1195
University of Insubria · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the discovery of the human T-cell leukemia virus-1 (HTLV-1), cellular and animal models have provided invaluable contributions in the knowledge of viral infection, transmission and progression of HTLV-associated diseases. HTLV-1 is the causative agent of the aggressive adult T-cell leukemia/lymphoma and inflammatory diseases such as the HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Cell models contribute to defining the role of HTLV proteins, as well as the mechanisms of cell-to-cell transmission of the virus. Otherwise, selected and engineered animal models are currently applied to recapitulate in vivo the HTLV-1 associated pathogenesis and to verify the effectiveness of viral therapy and host immune response. Here we review the current cell models for studying virus-host interaction, cellular restriction factors and cell pathway deregulation mediated by HTLV products. We recapitulate the most effective animal models applied to investigate the pathogenesis of HTLV-1-associated diseases such as transgenic and humanized mice, rabbit and monkey models. Finally, we summarize the studies on STLV and BLV, two closely related HTLV-1 viruses in animals. The most recent anticancer and HAM/TSP therapies are also discussed in view of the most reliable experimental models that may accelerate the translation from the experimental findings to effective therapies in infected patients.

Indexed as

Disease Models, AnimalHTLV-I InfectionsHuman T-lymphotropic virus 1Leukemia-Lymphoma, Adult T-CellAnimalsHumansMiceMice, TransgenicATLBLVCIITACRISPRHAM/TSPHBZHTLVhumanized miceNF-κBrestriction factorsSTLVTax

Identifiers

PMID34360767
PMCPMC8347336
OpenAlexW3184408627

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.