Evidence map›Paper›PMID 34360849›Full record

ReviewInternational journal of molecular sciences2021

Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta.

Andrea Olmos-Ortiz, Pilar Flores-Espinosa, Lorenza Díaz, Pilar Velázquez, Carlos Ramírez-Isarraraz, Verónica Zaga-Clavellina

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
  2. Transient fetal hyperglycemia reprograms adipogenesis, lipogenesis, and insulin signaling in zebrafish.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Early Postpartum IL-10 and IL-37 Concentrations in Women with Gestational Diabetes Mellitus.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Review
  13. Article
  14. Hyperglycemia enhances group BFrontiers in immunology · 2025
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Placental-Heart Axis: An Evolutionary Perspective.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrea Olmos-OrtizDepartamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes (INPer), Ciudad de México 11000, Mexico.ORCID 0000-0002-5456-9695
Pilar Flores-EspinosaDepartamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes (INPer), Ciudad de México 11000, Mexico.ORCID 0000-0003-2140-3629
Lorenza DíazDepartamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, Mexico.ORCID 0000-0002-5947-4222
Pilar VelázquezDepartamento de Ginecología y Obstetricia, Hospital Ángeles México, Ciudad de México 11800, Mexico.
Carlos Ramírez-IsarrarazClínica de Urología Ginecológica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes (INPer), Ciudad de México 11000, Mexico.
Verónica Zaga-ClavellinaDepartamento de Fisiología y Desarrollo Celular, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes (INPer), Ciudad de México 11000, Mexico.ORCID 0000-0002-3365-2932

Funding

Consejo Nacional de Ciencia y Tecnología CB-A1-S-27832Instituto Nacional de Perinatología 2018-1-152Instituto Nacional de Perinatología 2019-1-5
6 · The paper itself

Abstract

Gestational Diabetes Mellitus (GDM) is a transitory metabolic condition caused by dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and endothelial cells, and insulin resistance during pregnancy. However, this disease includes not only changes related to metabolic distress but also placental immunoendocrine adaptations, resulting in harmful effects to the mother and fetus. In this review, we focus on the placenta as an immuno-endocrine organ that can recognize and respond to the hyperglycemic environment. It synthesizes diverse chemicals that play a role in inflammation, innate defense, endocrine response, oxidative stress, and angiogenesis, all associated with different perinatal outcomes.

Indexed as

Diabetes, GestationalEndothelial CellsFetusHyperglycemiaPlacentaFemaleHumansPregnancyadipokinesangiogenesisantimicrobial peptidescytokinesIGF-Iinflammationinsulinlactotroph hormonesmetabolic stressoxidative stress

Identifiers

PMID34360849
PMCPMC8348825

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.