Evidence map›Paper›PMID 34360899›Full record

ArticleInternational journal of molecular sciences2021

The Role of Caspase-12 in Retinal Bystander Cell Death and Innate Immune Responses against MCMV Retinitis.

Xinyan Zhang, Jinxian Xu, Brendan Marshall, Zheng Dong, Sylvia B Smith, Ming Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xinyan ZhangDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Jinxian XuDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Brendan MarshallDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Zheng DongDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-3538-8095
Sylvia B SmithDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Ming ZhangDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-4012-3932
Augusta University · US

Funding

Module 3: Gene Expression/ProteomicsP30EY031631 · NEI · AUGUSTA UNIVERSITY · PI Xingjun Fan · 2020 to 2026
$3.6M
Mechanism of death of bystander retinal cells during MCMV infectionR01EY026642 · NEI · AUGUSTA UNIVERSITY · PI ZHANG, MING · 2016 to 2020
$1.5M
NEI NIH HHS P30 EY031631NEI NIH HHS R01 EY026642NIH HHS P30 EY031631NIH HHS RO1 EY026642
6 · The paper itself

Abstract

(1) Background: caspase-12 is activated during cytomegalovirus retinitis, although its role is presently unclear. (2) Methods:

Indexed as

AnimalsApoptosisCaspase 12Cytomegalovirus RetinitisFemaleImmunity, InnateIn Situ Nick-End LabelingInterferonsMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMuromegalovirusRetinaRetinal NeuronsCasp12 protein, mouseCaspase 12InterferonsTrp53 protein, mouseTumor Suppressor Protein p53caspase-12caspase-3interferonsmurine cytomegalovirusp53

Identifiers

PMID34360899
PMCPMC8348425
OpenAlexW3185041283

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.