Evidence mapPaperPMID 34362178Full record

ArticleJournal of clinical medicine2021

The Procoagulant Effect of COVID-19 on the Thrombotic Risk of Patients with Hip Fractures Due to Enhanced Clot Strength and Fibrinolysis Shutdown.

Andreas G Tsantes, Dimitrios V Papadopoulos, Ioannis G Trikoupis, Stavros Goumenos, Daniele Piovani, Konstantina A Tsante, Andreas F Mavrogenis, Aristeidis G Vaiopoulos, Panagiotis Koulouvaris, Georgios K Nikolopoulos and 3 more

Abstract read
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Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andreas G TsantesLaboratory of Haematology and Blood Bank Unit, "Attiko" Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-3695-0759
Dimitrios V PapadopoulosDepartment of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15237, USA.
Ioannis G TrikoupisFirst Department of Orthopaedics, National and Kapodistrian, School of Medicine, University of Athens, 12462 Athens, Greece.
Stavros GoumenosFirst Department of Orthopaedics, National and Kapodistrian, School of Medicine, University of Athens, 12462 Athens, Greece.
Daniele PiovaniDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy.
Konstantina A TsanteLaboratory of Haematology and Blood Bank Unit, "Attiko" Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Andreas F MavrogenisFirst Department of Orthopaedics, National and Kapodistrian, School of Medicine, University of Athens, 12462 Athens, Greece.ORCID 0000-0003-0807-0719
Aristeidis G VaiopoulosLaboratory of Haematology and Blood Bank Unit, "Attiko" Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Panagiotis KoulouvarisFirst Department of Orthopaedics, National and Kapodistrian, School of Medicine, University of Athens, 12462 Athens, Greece.
Georgios K NikolopoulosDepartment of Epidemiology and Public Health, Medical School, University of Cyprus, Nicosia 1678, Cyprus.
Panayiotis J PapagelopoulosFirst Department of Orthopaedics, National and Kapodistrian, School of Medicine, University of Athens, 12462 Athens, Greece.
Stefanos BonovasDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy.ORCID 0000-0001-6102-6579
Argirios E TsantesLaboratory of Haematology and Blood Bank Unit, "Attiko" Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCoronavirus disease 2019 (COVID-19) in patients with hip fractures is associated with increased incidence of venous thromboembolism (VTE). The purpose of this study was to evaluate the hemostatic alterations of COVID-19 that are associated with a higher thrombotic risk using rotational thromboelastometry (ROTEM).

methodsA retrospective observational study was performed including 20 COVID-19 patients with hip fractures. To compare the coagulopathy of patients with mild COVID-19 and hip fractures with the coagulopathy associated with each of these two conditions separately, we used two previously recruited groups of patients; 198 hip fracture patients without COVID-19 and 21 COVID-19 patients without hip fractures. The demographics, clinical parameters, conventional coagulation parameters and ROTEM findings of the three groups were analyzed and compared.

resultsCOVID-19 hip fracture patients had higher amplitude of clot firmness at 10 min ( DISCUSSION: The higher thrombotic risk in COVID-19 patients with hip fractures is characterized by increased clot strength and fibrinolysis shutdown, as shown by ROTEM findings. Further prospective studies are warranted to evaluate the need for modification of thromboprophylaxis to balance the hemostatic derangements of COVID-19 patients with hip fractures.

Indexed as

coagulopathyCOVID-19fibrinolysis shutdownhip fracturesthrombotic risk

Identifiers

PMID34362178
PMCPMC8347467

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.