Evidence map›Paper›PMID 34366297›Full record

ArticleJournal of neurogastroenterology and motility2022

Efficacy of acotiamide on postprandial distress syndrome and epigastric pain syndrome depending on the estimated gastric acid secretion level.

Toshiaki Suzuki, Reina Ohba, Ei Kataoka, Yui Kudo, Akira Zeniya, Daisuke Segawa, Keisuke Oikawa, Masaru Odashima, Taiji Saga, Tomoyuki Kuramitsu and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurogastroenterology and motility, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Efficacy of Acotiamide in Pediatric Patients with Functional Dyspepsia.Pediatric gastroenterology, hepatology & nutrition · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Toshiaki SuzukiDepartment of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.
Reina OhbaDepartment of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.
Ei KataokaKataoka Internal Medicine Clinic, Akita, Japan.
Yui KudoKudo Gastroenterology Clinic, Akita, Japan.
Akira ZeniyaZeniya Clinic, Akita, Japan.
Daisuke SegawaSegawa Clinic, Noshiro, Japan.
Keisuke OikawaOikawa Clinic, Akita, Japan.
Masaru OdashimaOdashima Masaru Clinic, Yokote, Japan.
Taiji SagaMatsugasaki Clinic, Akita, Japan.
Tomoyuki KuramitsuKuramitsu Clinic, Akita, Japan.
Hideaki SasaharaSasahara Internal Medicine Clinic, Akita, Japan.
Kazuo YoneyamaYoneyama Gastroenterology Clinic, Akita, Japan.
Takashi TomitaTomita Gastroenterology Clinic, Akita, Japan.
Yosuke ShimodairaDepartment of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.
Katsunori IijimaDepartment of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.ORCID https://orcid.org/0000-0003-3482-9979
Akebono Clinic · JPAkita University · JPSegawa Neurological Clinic for Children · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsGastric acid secretion is suspected to be a pivotal contributor to the pathogenesis of functional dyspepsia. The present study investigates the potential association of the gastric acid secretion estimated by measuring serum pepsinogen with therapeutic responsiveness to the prokinetic drug acotiamide.

methodsDyspeptic patients consulting participating clinics from October 2017 to March 2019 were prospectively enrolled in the study. The dyspeptic symptoms were classified into postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). Gastric acid secretion levels were estimated by the

resultsOf the 86 enrolled patients, 56 (65.1%) and 26 (30.2%) were classified into PDS and EPS, respectively. The estimated gastric acid secretion was not significantly different between PDS and EPS. The response rates were 66.0% for PDS and 73.1% for EPS, showing no significant difference. While the response rates were stable, ranging from 61.0% to 75.0% regardless of the estimated gastric acid secretion level among subjects with PDF, the rates were significantly lower in hyper-secretors than in non-hyper-secretors among subjects with EPS (42.0% vs 83.0%,

conclusionAlthough acotiamide is effective for treating EPS as well as PDS overall, the efficacy is somewhat limited in EPS with gastric acid hypersecretion, with gastric acid suppressants, such as proton pump inhibitors, being more suitable.

Indexed as

AcotiamideEpigastric pain syndromeGastric acid secretionPostprandial distress syndromeSerum pepsinogen

Identifiers

PMID34366297
PMCPMC8748858
OpenAlexW3193220426

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.