Evidence map›Paper›PMID 34368229›Full record

ReviewFrontiers in molecular biosciences2021

Biomedical Applications of Supramolecular Materials in the Controllable Delivery of Steroids.

Yun Hao, Feiyi Zhang, Shanshan Mo, Jinming Zhao, Xiangdong Wang, Yan Zhao, Luo Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Perspectives in Therapy of Chronic Rhinosinusitis.Diagnostics (Basel, Switzerland) · 2022
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Yun HaoDepartment of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Feiyi ZhangInstitute for Advanced Materials, Jiangsu University, Zhenjiang, China.
Shanshan MoState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Jinming ZhaoDepartment of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Xiangdong WangDepartment of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Yan ZhaoDepartment of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Luo ZhangDepartment of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Beijing Institute of Neurosurgery · CNBeijing Tongren Hospital · CNCapital Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNJiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucocorticoids are a class of steroid hormones secreted from the adrenal glands. The strong anti-inflammatory effects make it be one of the most popular and versatile drugs available to treat chronic inflammatory diseases. Additionally, supramolecular materials have been widely exploited in drug delivery, due to their biocompatibility, tunability, and predictability. Thus, steroid-based supramolecular materials and the release of steroids have been applied in the treatment of inflammatory diseases. This mini-review summarized recent advances in supramolecular materials loaded with glucocorticoid drugs in terms of hydrophobic interactions, electrostatic interactions, hydrogen bonding, and π-π stackings. We also discussed and prospected the application of the glucocorticoid drugs-based supramolecular system on chronic rhinosinusitis, multifactorial inflammatory disease of the nasal and paranasal sinuses mucosal membranes. Overall, supramolecular materials can provide an alternative to traditional materials as a novel delivery platform in clinical practice.

Indexed as

biomedical applicationchronic rhinosinusitisinteractionsteroidssupramolecular materials

Identifiers

PMID34368229
PMCPMC8343020
OpenAlexW3183532874

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.