Evidence mapPaperPMID 34368807Full record

ArticleAdvances in geriatric medicine and research2021

Obesity, Vascular Disease and Frailty in Aging Women with HIV.

Deborah R Gustafson, Samy I McFarlane

Open access · diamondAbstract read
In one paragraph

Article in Advances in geriatric medicine and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Deborah R GustafsonSection for NeuroEpidemiology, Department of Neurology, State University of New York Downstate Health Sciences University, Brooklyn, New York, NY 11203, USA.
Samy I McFarlaneDivision of Endocrinology, Department of Medicine, College of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, New York, NY 11203, USA.
State University of New York · US

Funding

Women's Interagency HIV Study (WIHS) IIIU01AI031834 · SUNY DOWNSTATE MEDICAL CENTER · 1998 to 2005
$15.4M
MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS)U01HL146202 · SUNY DOWNSTATE MEDICAL CENTER · 2025 to 2025
$2.9M
NHLBI NIH HHS U01 HL146202NIAID NIH HHS U01 AI031834
6 · The paper itself

Abstract

Women with chronic HIV infection (WWH) living in the United States, experience a disproportionately high rate of obesity compared to uninfected populations. Both overweight and obesity, particularly central obesity, are major contributors to insulin resistance, hypertension, and dyslipidemia-the major components of metabolic syndromes, including type 2 diabetes, and leading to increased cardiovascular risk, including coronary heart disease, and cerebrovascular diseases. Notably, declining physical performance and frailty co-occur with vascular morbidities as well as changes in bone. These factors tend to exacerbate each other and accelerate the aging trajectory, leading to poorer quality of life, cognitive impairments, dementia, and eventually, death. In WWH, persistent HIV infection, sustained treatment for HIV infection, and concomitant obesity, may accelerate aging-related morbidities and poorer aging outcomes. Furthermore, health disparities factors common among some WWH, are independently associated with obesity and higher vascular risk. The purpose of this review is to describe the constellation of obesity, cardio- and cerebrovascular diseases, bone health and frailty among aging WWH, a 21st century emergence.

Indexed as

agingbonecardiovascular diseasefrailtyHIVobesity

Identifiers

PMID34368807
PMCPMC8345026
OpenAlexW3176478735

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.