Evidence map›Paper›PMID 34370289›Full record

ArticleAdvances in experimental medicine and biology2021

Small Molecule Regulators of Ferroptosis.

Sylvain Debieu, Stéphanie Solier, Ludovic Colombeau, Antoine Versini, Fabien Sindikubwabo, Alison Forrester, Sebastian Müller, Tatiana Cañeque, Raphaël Rodriguez

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sylvain DebieuInstitut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Stéphanie SolierInstitut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Ludovic ColombeauInstitut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Antoine VersiniInstitut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Fabien SindikubwaboInstitut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Alison ForresterInstitut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Sebastian MüllerInstitut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Tatiana CañequeInstitut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Raphaël RodriguezInstitut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France. Raphael.Rodriguez@curie.fr.
Institut Curie · FRCentre National de la Recherche Scientifique · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is a dedicated mode of cell death involving iron, reactive oxygen species and lipid peroxidation. Involved in processes such as glutathione metabolism, lysosomal iron retention or interference with lipid metabolism, leading either to activation or inhibition of ferroptosis. Given the implications of ferroptosis in diseases such as cancer, aging, Alzheimer and infectious diseases, new molecular mechanisms underlying ferroptosis and small molecules regulators that target those mechanisms have prompted a great deal of interest. Here, we discuss the current scenario of small molecules modulating ferroptosis and critically assess what is known about their mechanisms of action.

Indexed as

FerroptosisCell DeathHumansIronLipid PeroxidationReactive Oxygen SpeciesIronReactive Oxygen SpeciesFenton reactionIronLipid peroxidationReactive oxygen speciesSmall molecule

Identifiers

PMID34370289
OpenAlexW3193070683

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.