Evidence map›Paper›PMID 34371867›Full record

SynthesisNutrients2021

Folic Acid Supplementation Improves Glycemic Control for Diabetes Prevention and Management: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.

Omid Asbaghi, Damoon Ashtary-Larky, Reza Bagheri, Seyedeh Parisa Moosavian, Hadi Pourmirzaei Olyaei, Behzad Nazarian, Mahnaz Rezaei Kelishadi, Alexei Wong, Darren G Candow, Frédéric Dutheil and 2 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 7 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 7 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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  13. Sumac (Current developments in nutrition · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 5 countries.

Omid AsbaghiCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1416753955, Iran.
Damoon Ashtary-LarkyNutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran.
Reza BagheriDepartment of Exercise Physiology, University of Isfahan, Isfahan 8174673441, Iran.
Seyedeh Parisa MoosavianDepartment of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 8174673461, Iran.ORCID 0000-0002-5990-1984
Hadi Pourmirzaei OlyaeiDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran 1584743311, Iran.
Behzad NazarianStudent Research Committee, Lorestan University of Medical Sciences, Khorramabad 6813833946, Iran.
Mahnaz Rezaei KelishadiDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 8174673461, Iran.
Alexei WongDepartment of Health and Human Performance, Marymount University, Arlington, VA 22207, USA.
Darren G CandowFaculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4S OA2, Canada.
Frédéric DutheilCNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Preventive and Occupational Medicine, Université Clermont Auvergne, WittyFit, F-63000 Clermont-Ferrand, France.
Katsuhiko SuzukiFaculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa 359-1192, Japan.ORCID 0000-0002-6572-5809
Amirmansour Alavi NaeiniDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 8174673461, Iran.
Isfahan University of Medical Sciences · IRAhvaz Jundishapur University of Medical Sciences · IRCentre National de la Recherche Scientifique · FRIslamic Azad University, Science and Research Branch · IRLorestan University of Medical Sciences · IRMarymount University · USShahid Beheshti University of Medical Sciences · IRUniversity of Isfahan · IRUniversity of Regina · CAWaseda University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a growing interest in the considerable benefits of dietary supplementations, such as folic acid, on the glycemic profile. We aimed to investigate the effects of folic acid supplementation on glycemic control markers in adults.

methodsRandomized controlled trials examining the effects of folic acid supplementation on glycemic control markers published up to March 2021 were detected by searching online databases, including Scopus, PubMed, Embase, and ISI web of science, using a combination of related keywords. Mean change and standard deviation (SD) of the outcome measures were used to estimate the mean difference between the intervention and control groups at follow-up. Meta-regression and non-linear dose-response analysis were conducted to evaluate the association between pooled effect size and folic acid dosage (mg/day) and duration of the intervention (week). From 1814 detected studies, twenty-four studies reported fasting blood glucose (FBG), fasting insulin, hemoglobin A1C (HbA1C), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) as an outcome measure.

resultsResults revealed significant reductions in FBG (weighted mean difference (WMD): -2.17 mg/dL, 95% CI: -3.69, -0.65,

conclusionsFolic acid supplementation significantly reduces some markers of glycemic control in adults. These reductions were small, which may limit clinical applications for adults with type II diabetes. Further research is necessary to confirm our findings.

Indexed as

Dietary SupplementsAdultBlood GlucoseDiabetes Mellitus, Type 2FastingFemaleFolic AcidGlycated HemoglobinGlycemic ControlHumansInsulinInsulin ResistanceMaleMiddle AgedRandomized Controlled Trials as TopicRegression AnalysisBlood GlucoseFolic AcidGlycated Hemoglobinhemoglobin A1c protein, humanInsulindiabetesfolic acidglycemic controlmeta-analysis

Identifiers

PMID34371867
PMCPMC8308657
OpenAlexW3180130918

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.