Evidence map›Paper›PMID 34371907›Full record

Trial reportNutrients2021

Effect of Coffee and Cocoa-Based Confectionery Containing Coffee on Markers of DNA Damage and Lipid Peroxidation Products: Results from a Human Intervention Study.

Daniela Martini, Raúl Domínguez-Perles, Alice Rosi, Michele Tassotti, Donato Angelino, Sonia Medina, Cristian Ricci, Alexandre Guy, Camille Oger, Letizia Gigliotti and 15 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Coffee as a Source of Antioxidants and an Elixir of Youth.Antioxidants (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 8 institutions in 4 countries.

Daniela MartiniDepartment of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0001-8298-926X
Raúl Domínguez-PerlesResearch Group on Quality, Safety, and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, Espinardo, 30100 Murcia, Spain.ORCID 0000-0001-6232-712X
Alice RosiHuman Nutrition Unit, Department of Food and Drugs, University of Parma, 43125 Parma, Italy.ORCID 0000-0001-8533-797X
Michele TassottiHuman Nutrition Unit, Department of Food and Drugs, University of Parma, 43125 Parma, Italy.
Donato AngelinoFaculty of Bioscience and Technology for Food, Agriculture, and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0002-5436-7428
Sonia MedinaResearch Group on Quality, Safety, and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, Espinardo, 30100 Murcia, Spain.
Cristian RicciPediatric Epidemiology, Department of Pediatrics, University Medicine Leipzig, 04103 Leipzig, Germany.ORCID 0000-0003-4113-8682
Alexandre GuyInstitut des Biomolécules Max Mousseron, IBMM, University of Montpellier, CNRS, ENSCM, 34093 Montpellier, France.
Camille OgerInstitut des Biomolécules Max Mousseron, IBMM, University of Montpellier, CNRS, ENSCM, 34093 Montpellier, France.ORCID 0000-0002-5177-5792
Letizia GigliottiDepartment of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0002-7739-2378
Thierry DurandInstitut des Biomolécules Max Mousseron, IBMM, University of Montpellier, CNRS, ENSCM, 34093 Montpellier, France.
Mirko MarinoDepartment of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0001-9913-4380
Hans Gottfried-GenieserBIOLOG Life Science Institute, 28199 Bremen, Germany.
Marisa PorriniDepartment of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0003-2693-3311
Monica AntoniniDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Alessandra Dei CasDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0002-8666-4849
Riccardo C BonadonnaDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Federico FerreresDepartment of Food Technology and Nutrition, Molecular Recognition and Encapsulation (REM) Group, Universidad Católica de Murcia, UCAM, 30107 Murcia, Spain.
Francesca ScazzinaHuman Nutrition Unit, Department of Food and Drugs, University of Parma, 43125 Parma, Italy.ORCID 0000-0002-5372-8658
Furio BrighentiHuman Nutrition Unit, Department of Food and Drugs, University of Parma, 43125 Parma, Italy.ORCID 0000-0001-8441-4611
Patrizia RisoDepartment of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0002-9204-7257
Cristian Del Bo'Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0001-7562-377X
Pedro MenaHuman Nutrition Unit, Department of Food and Drugs, University of Parma, 43125 Parma, Italy.ORCID 0000-0003-2150-2977
Angel Gil-IzquierdoResearch Group on Quality, Safety, and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, Espinardo, 30100 Murcia, Spain.ORCID 0000-0001-7646-0386
Daniele Del RioHuman Nutrition Unit, Department of Food and Drugs, University of Parma, 43125 Parma, Italy.ORCID 0000-0001-5394-1259
University of Parma · ITUniversity of Milan · ITCentro de Edafología y Biología Aplicada del Segura · ESÉcole Nationale Supérieure de Chimie de Montpellier · FRBiolog Life Science Institute · DEUniversidad Católica de Murcia · ESUniversity Hospital Leipzig · DEUniversity of Teramo · IT

Funding

Soremartec Italia S.r.l. xxx
6 · The paper itself

Abstract

The effect of coffee and cocoa on oxidative damage to macromolecules has been investigated in several studies, often with controversial results. This study aimed to investigate the effect of one-month consumption of different doses of coffee or cocoa-based products containing coffee on markers of DNA damage and lipid peroxidation in young healthy volunteers. Twenty-one volunteers were randomly assigned into a three-arm, crossover, randomized trial. Subjects were assigned to consume one of the three following treatments: one cup of espresso coffee/day (1C), three cups of espresso coffee/day (3C), and one cup of espresso coffee plus two cocoa-based products containing coffee (PC) twice per day for 1 month. At the end of each treatment, blood samples were collected for the analysis of endogenous and H

Indexed as

ChocolateCoffeeDNA DamageLipid PeroxidationOxidative Stress8-Hydroxy-2'-DeoxyguanosineBiomarkersChromatography, High Pressure LiquidComet AssayCross-Over StudiesCyclic GMPFemaleGuanineHumansMaleTandem Mass Spectrometry8-Hydroxy-2'-Deoxyguanosine8-hydroxyguanine8-nitroguanosine 3',5'-cyclic monophosphateBiomarkersCoffeeCyclic GMPGuaninecoffeecomet assayDNA damagelipid peroxidationoxidative stressrandomized controlled trial

Identifiers

PMID34371907
PMCPMC8308525
OpenAlexW3178458503

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.