Evidence map›Paper›PMID 34377708›Full record

ArticleBurns & trauma2021

Low-protein diet accelerates wound healing in mice post-acute injury.

Jonathan J Hew, Roxanne J Parungao, Craig P Mooney, Julian K Smyth, Sarah Kim, Kevin H-Y Tsai, Huaikai Shi, Cassandra Chong, Renee C F Chan, Beba Attia and 8 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns & trauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 3 countries.

Jonathan J HewBurns Research and Reconstructive Surgery, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
Roxanne J ParungaoBurns Research and Reconstructive Surgery, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
Craig P MooneyBurns Research and Reconstructive Surgery, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
Julian K SmythBurns Research and Reconstructive Surgery, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
Sarah KimBone Biology Group, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
Kevin H-Y TsaiAdrenal Steroids Laboratory, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
Huaikai ShiBurns Research and Reconstructive Surgery, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.ORCID https://orcid.org/0000-0002-8269-2981
Cassandra ChongBurns Research and Reconstructive Surgery, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
Renee C F ChanElectron Microscopy Unit, Anatomical Pathology, Concord Hospital, Sydney, Australia 2139.
Beba AttiaElectron Microscopy Unit, Anatomical Pathology, Concord Hospital, Sydney, Australia 2139.
Caroline NichollsBurns Unit, Concord Repatriation General Hospital, Concord, Australia 2139.
Zhe LiBurns Research and Reconstructive Surgery, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
Samantha M Solon-BietAgeing and Alzheimer Institute and ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
David G Le CouteurAgeing and Alzheimer Institute and ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
Stephen J SimpsonCharles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, Australia 2006.
Marc G JeschkeSunnybrook Research Institute, Toronto, Ontario, Canada, M4N 3M5.
Peter K MaitzBurns Research and Reconstructive Surgery, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
Yiwei WangBurns Research and Reconstructive Surgery, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.ORCID https://orcid.org/0000-0001-6585-6641
The University of Sydney · AUConcord Repatriation General Hospital · AUSunnybrook Health Science Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWound healing processes are influenced by macronutrient intake (protein, carbohydrate and fat). The most favourable diet for cutaneous wound healing is not known, although high-protein diets are currently favoured clinically. This experimental study investigates the optimal macronutrient balance for cutaneous wound healing using a mouse model and the Geometric Framework, a nutrient modelling method, capable of analyzing the individual and interactive effects of a wide spectrum of macronutrient intake.

methodsTwo adjacent and identical full-thickness skin excisions (1 cm

resultsUsing the Geometric Framework, we show that a low-protein intake, coupled with a balanced intake of carbohydrate and fat is optimal for wound healing. Mice fed a low-protein diet progressed quickly through wound healing stages with favourable wound inflammatory cytokine expression and significantly accelerated collagen production. These local processes were associated with an increased early systemic inflammatory response and a higher overall energy expenditure, related to metabolic changes occurring in key macronutrient reserves in lean body mass and fat depots.

conclusionsThe results suggest that a low-protein diet may have a greater potential to accelerate wound healing than the current clinically used high-protein diets.

Indexed as

CutaneousGeometric FrameworkLow-protein dietMacronutrientsMouse modelNutritionWound healing

Identifiers

PMID34377708
PMCPMC8350350
OpenAlexW3188962048

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.