Evidence map›Paper›PMID 34381739›Full record

ArticleFrontiers in cellular and infection microbiology2021

Treatment With Suboptimal Dose of Benznidazole Mitigates Immune Response Molecular Pathways in Mice With Chronic Chagas Cardiomyopathy.

Priscila Silva Grijó Farani, Khodeza Begum, Glaucia Vilar-Pereira, Isabela Resende Pereira, Igor C Almeida, Sourav Roy, Joseli Lannes-Vieira, Otacilio Cruz Moreira

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Priscila Silva Grijó FaraniReal Time PCR Platform RPT09A, Laboratory of Molecular Biology and Endemic Diseases, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Khodeza BegumDepartment of Biological Sciences, Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX, United States.
Glaucia Vilar-PereiraLaboratory of Biology of the Interactions, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Isabela Resende PereiraLaboratory of Biology of the Interactions, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Igor C AlmeidaDepartment of Biological Sciences, Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX, United States.
Sourav RoyDepartment of Biological Sciences, Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX, United States.
Joseli Lannes-VieiraLaboratory of Biology of the Interactions, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Otacilio Cruz MoreiraReal Time PCR Platform RPT09A, Laboratory of Molecular Biology and Endemic Diseases, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Fundação Oswaldo Cruz · BRThe University of Texas at El Paso · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic Chagas cardiomyopathy (CCC) is the most frequent and severe form of Chagas disease, a neglected tropical illness caused by the protozoan

Indexed as

Chagas CardiomyopathyChagas DiseaseTrypanosoma cruziAnimalsImmunityMiceMice, Inbred C57BLNitroimidazolesbenzonidazoleNitroimidazolesbenznidazolecardiomyopathyChagas diseaseimmune responsepentoxifyllineTaqMan arrayTrypanosoma cruzi

Identifiers

PMID34381739
PMCPMC8351877
OpenAlexW3180100062

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.