Evidence map›Paper›PMID 34382134›Full record

Trial reportSleep & breathing = Schlaf & Atmung2022

Blood glucose dynamics during sleep in patients with obstructive sleep apnea and normal glucose tolerance: effects of CPAP therapy.

Kimimasa Saito, Yosuke Okada, Keiichi Torimoto, Yoko Takamatsu, Yoshiya Tanaka

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep & breathing = Schlaf & Atmung, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Continuous Glucose Monitoring Among People with and without Diabetes Mellitus and Sleep Apnoea.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kimimasa SaitoSaito Naika Kokyukika, Mie Sleep Clinic, 446 Sogo, Obata-chyo, Ise-shi, Mie, 519-0502, Japan. k1saito@carrot.ocn.ne.jp.
Yosuke OkadaFirst Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushyu-shi, 807-8555, Japan.
Keiichi TorimotoFirst Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushyu-shi, 807-8555, Japan.
Yoko TakamatsuSaito Naika Kokyukika, Mie Sleep Clinic, 446 Sogo, Obata-chyo, Ise-shi, Mie, 519-0502, Japan.
Yoshiya TanakaFirst Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushyu-shi, 807-8555, Japan.
University of Occupational and Environmental Health Japan · JPUnitika (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGlycemic variability (GV) and hypoglycemia during nighttime are presumed to be associated with fatal bradycardia. The aim of this prospective study was to evaluate blood glucose dynamics during sleep in patients with obstructive sleep apnea syndrome (OSA) and normal glucose tolerance.

methodsPatients with OSA and no diabetes who underwent type 1 overnight polysomnography from December 2018 to May 2020 participated in this study. GV was evaluated in all participants for 14 days using a flash glucose monitoring device. Correlations were examined between GV indexes and indexes related to sleep breathing disorders, the effects of treatment with continuous positive airway pressure (CPAP) on these GV indexes, and the characteristics of glucose dynamics in different OSA subtypes classified by sleep stage.

resultsAmong 42 patients with OSA and no diabetes, the standard deviation of GV during sleep correlated significantly with sleep time spent with oxygen saturation <90% (r=0.591, p=0.008). High blood glucose index during sleep correlated significantly with stage N1% (r=0.491, p=0.032) and negatively with stage N2% (r=-0.479, p=0.038). High blood glucose index correlated significantly with sleep time spent with oxygen saturation <90% (r=0.640, p=0.003). The rapid eye movement-related OSA group had a higher incidence of hypoglycemia. One-week with CPAP treatment significantly improved GV during sleep, standard deviation of GV (from 12.1 to 9.0 mg/dL, p<0.001), and high blood glucose index (from 0.7 to 0.4, p=0.006).

conclusionsTo evaluate GV during sleep in patients with OSA may be useful for clinical risk management. CPAP treatment for 1 week may have an improving GV and high blood glucose index. CLINICAL

trial registrationUMIN000038489 2019/11/04, UMIN 000025433 2016/12/27.

Indexed as

HypoglycemiaSleep Apnea, ObstructiveBlood GlucoseBlood Glucose Self-MonitoringContinuous Positive Airway PressureGlucoseHumansProspective StudiesSleepBlood GlucoseGlucoseContinuous glucose monitoringContinuous positive airway pressureFlush glucose monitoringGlycemic variability during sleepObstructive sleep apneaREM-related obstructive sleep apnea

Identifiers

PMID34382134
PMCPMC9130196
OpenAlexW3193073469

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.