ArticleScientific reports2021
Acquired olfactory loss alters functional connectivity and morphology.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neurobiological mechanisms of olfactory dysfunction: a ten-year bibliometric and visualization analysis.Frontiers in medicine · 2026Pooled it
- Olfactory system measurements in COVID-19: a systematic review and meta-analysis.Neuroradiology · 2023Pooled it
- Possible Volumetric Changes in the Hippocampus and Olfactory Bulbs After COVID-19: A Stereological MRI Study.Viruses · 2026Article
- Review
- Autonomic and neurosensory disorders in dementia with lewy bodies: prevalence and neural basis in the AlphaLewyMA cohort.Alzheimer's research & therapy · 2025Article
- Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson's patients with hyposmia.NPJ systems biology and applications · 2025Article
- Mapping the Olfactory Brain: A Systematic Review of Structural and Functional Magnetic Resonance Imaging Changes Following COVID-19 Smell Loss.Brain sciences · 2025Review
- The olfactory functional network in the Alzheimer's disease continuum: a resting state fMRI study.Frontiers in aging neuroscience · 2025Article
- Article
- What Does the Human Olfactory System Do, and How Does It Do It?Annual review of psychology · 2024Review
- Diabetic Neuropathy Is Related to Rhinencephalon Degeneration in Adults With Type 1 Diabetes.Journal of diabetes research · 2024Article
- fNIRS a novel neuroimaging tool to investigate olfaction, olfactory imagery, and crossmodal interactions: a systematic review.Frontiers in neuroscience · 2024Review
- Beyond anosmia: olfactory dysfunction as a common denominator in neurodegenerative and neurodevelopmental disorders.Frontiers in neuroscience · 2024Review
- Lifelong olfactory deprivation-dependent cortical reorganization restricted to orbitofrontal cortex.Human brain mapping · 2023Article
- Altered structural connectivity in olfactory disfunction after mild COVID-19 using probabilistic tractography.Scientific reports · 2023Article
- Aberrant olfactory network functional connectivity in people with olfactory dysfunction following COVID-19 infection: an exploratory, observational study.EClinicalMedicine · 2023Article
- Abnormal functional connectivity of the core olfactory network in patients with chronic rhinosinusitis accompanied by olfactory dysfunction.Frontiers in neurology · 2023Article
- Olfactory Loss and Brain Connectivity after COVID-19: Structural Follow-Up at One Year.Neural plasticity · 2023Article
- Olfactory loss and brain connectivity after COVID-19.Human brain mapping · 2022Article
- Possible Role of Endocannabinoids in Olfactory and Taste Dysfunctions in COVID-19 Patients and Volumetric Changes in the Brain.Chemosensory perception · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Removing function from a developed and functional sensory system is known to alter both cerebral morphology and functional connections. To date, a majority of studies assessing sensory-dependent plasticity have focused on effects from either early onset or long-term sensory loss and little is known how the recent sensory loss affects the human brain. With the aim of determining how recent sensory loss affects cerebral morphology and functional connectivity, we assessed differences between individuals with acquired olfactory loss (duration 7-36 months) and matched healthy controls in their grey matter volume, using multivariate pattern analyses, and functional connectivity, using dynamic connectivity analyses, within and from the olfactory cortex. Our results demonstrate that acquired olfactory loss is associated with altered grey matter volume in, among others, posterior piriform cortex, a core olfactory processing area, as well as the inferior frontal gyrus and angular gyrus. In addition, compared to controls, individuals with acquired anosmia displayed significantly stronger dynamic functional connectivity from the posterior piriform cortex to, among others, the angular gyrus, a known multisensory integration area. When assessing differences in dynamic functional connectivity from the angular gyrus, individuals with acquired anosmia had stronger connectivity from the angular gyrus to areas primary responsible for basic visual processing. These results demonstrate that recently acquired sensory loss is associated with both changed cerebral morphology within core olfactory areas and increase dynamic functional connectivity from olfactory cortex to cerebral areas processing multisensory integration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.