Evidence map›Paper›PMID 34385669›Full record

Trial reportGenetics in medicine : official journal of the American College of Medical Genetics2021

Impact of personal genomic risk information on melanoma prevention behaviors and psychological outcomes: a randomized controlled trial.

Amelia K Smit, Martin Allen, Brooke Beswick, Phyllis Butow, Hugh Dawkins, Suzanne J Dobbinson, Kate L Dunlop, David Espinoza, Georgina Fenton, Peter A Kanetsky and 14 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Genetics in medicine : official journal of the American College of Medical Genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Predictors of genetic risk recall among the participants of a randomized controlled precision prevention trial against melanoma.Genetics in medicine : official journal of the American College of Medical Genetics · 2023
    Trial
  4. Trial
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. Article
  10. Article
  11. Cutaneous melanoma.Nature reviews. Disease primers · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 9 institutions in 4 countries.

Amelia K SmitThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, NSW, Sydney, Australia.ORCID 0000-0002-5331-6370
Martin AllenElectrical and Computer Engineering, University of Canterbury, Christchurch, New Zealand.
Brooke BeswickThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, NSW, Sydney, Australia.
Phyllis ButowCentre for Medical Psychology and Evidence-based Decision-making, School of Psychology, The University of Sydney, Sydney, NSW, Australia.
Hugh DawkinsDivision of Genetics, School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.
Suzanne J DobbinsonCancer Council Victoria, Melbourne, VIC, Australia.
Kate L DunlopThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, NSW, Sydney, Australia.
David EspinozaNHMRC Clinical Trials Centre, The University of Sydney, Sydney, NSW, Australia.
Georgina FentonThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, NSW, Sydney, Australia.
Peter A KanetskyH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Louise KeoghMelbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.
Michael G KimlinQueensland University of Technology, School of Biomedical Sciences, Brisbane, QLD, Australia.
Judy KirkWestmead Clinical School and Westmead Institute for Medical Research, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.
Matthew H LawStatistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Serigne LoMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Cynthia LowConsumer representative, Brisbane, QLD, Australia.
Graham J MannMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Gillian Reyes-MarcelinoThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, NSW, Sydney, Australia.
Rachael L MortonMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Ainsley J NewsonSydney Health Ethics, Sydney School of Public Health, The University of Sydney, Sydney, NSW, Australia.
Jacqueline SavardSchool of Medicine, Faculty of Health, Deakin University, Geelong, VIC, Australia.
Lyndal TrevenaSydney School of Public Health, The University of Sydney, Sydney, NSW, Australia.
Sarah WordsworthHealth Economics Research Centre, The University of Oxford, Oxford, UK.
Anne E CustThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, NSW, Sydney, Australia. anne.cust@sydney.edu.au.
The University of Sydney · AUQueensland University of Technology · AUCancer Council Victoria · AUDeakin University · AUMoffitt Cancer Center · USThe University of Melbourne · AUThe University of Western Australia · AUUniversity of Canterbury · NZUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe evaluated the impact of personal melanoma genomic risk information on sun-related behaviors and psychological outcomes.

methodsIn this parallel group, open, randomized controlled trial, 1,025 Australians of European ancestry without melanoma and aged 18-69 years were recruited via the Medicare database (3% consent). Participants were randomized to the intervention (n = 513; saliva sample for genetic testing, personalized melanoma risk booklet based on a 40-variant polygenic risk score, telephone-based genetic counseling, educational booklet) or control (n = 512; educational booklet). Wrist-worn ultraviolet (UV) radiation dosimeters (10-day wear) and questionnaires were administered at baseline, 1 month postintervention, and 12 months postbaseline.

resultsAt 12 months, 948 (92%) participants completed dosimetry and 973 (95%) the questionnaire. For the primary outcome, there was no effect of the genomic risk intervention on objectively measured UV exposure at 12 months, irrespective of traditional risk factors. For secondary outcomes at 12 months, the intervention reduced sunburns (risk ratio: 0.72, 95% confidence interval: 0.54-0.96), and increased skin examinations among women. Melanoma-related worry was reduced. There was no overall impact on general psychological distress.

conclusionPersonalized genomic risk information did not influence sun exposure patterns but did improve some skin cancer prevention and early detection behaviors, suggesting it may be useful for precision prevention. There was no evidence of psychological harm.

Indexed as

MelanomaSkin NeoplasmsAdolescentAdultAgedAustraliaFemaleGenomicsHumansMiddle AgedNational Health ProgramsYoung Adult

Identifiers

PMID34385669
PMCPMC8629758
OpenAlexW3190441124

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.