ArticleNature communications2021
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior.
Erratum issuedOpen access · goldAbstract read
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 60 papers.
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60citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
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Who cites it
60 citing papers in PubMed, 90 citations in OpenAlex.
- The cellular landscape of druggable RNA-binding proteins.Nature reviews. Drug discovery · 2026Review
- Epigenetic dysregulation in depression: molecular mechanisms, clinical biomarkers, and therapeutic opportunities.Journal of translational medicine · 2026Review
- tRNA methylation: functional insights and epitranscriptomic regulation.Cell communication and signaling : CCS · 2026Review
- The impact of psuedouridine modification on human tRNA.Biochemical Society transactions · 2026Review
- mBiology direct · 2026Review
- The RNA methyltransferase NSUN2 catalyzes 5-methylcytosine (mThe Journal of biological chemistry · 2026Article
- NSUN2 promoted tumor growth and metastatic via mCell death & disease · 2026Article
- Hidden in plain sight: illuminating the tRNA landscape by sequencing.Genome biology · 2026Review
- AI-driven virtual screening platform identifies novel NSUN2 inhibitor candidates for targeted cancer therapy: a computational drug discovery approach.NPJ precision oncology · 2026Article
- Emerging roles of tRNA modification-mediated codon-specific translational reprogramming in cancer biology.Cell death & disease · 2026Review
- Dysregulated mRNA Translation in Alzheimer's Disease: Mechanisms, Therapeutic Opportunities, and Challenges for Clinical Translation.Clinical interventions in aging · 2026Review
- Multi-omics analysis reveals that ALYREF-mediated mCell death & disease · 2025Article
- Diverse expression and modification of tRNAs and tRNA-derived RNAs in 19 mouse tissues.bioRxiv : the preprint server for biology · 2025Article
- Profiling fear-extinction learning induced small ncRNAs landscape and identifying miR-29b-3p as a promising biomarker for PTSD.Journal of translational medicine · 2025Article
- Comprehensive Explorations and Preliminary Experimental Verification of RNA Modification-Related Diagnostic Markers in the Subtype Classification of Peripheral Blood-Derived Mononuclear Cells Derived from Post-Traumatic Stress Disorder Patients.Diseases (Basel, Switzerland) · 2025Article
- Targeting tRNA methyltransferases: from molecular mechanisms to drug discovery.Science China. Life sciences · 2025Review
- Emerging roles of transfer RNA fragments in the CNS.Brain : a journal of neurology · 2025Review
- Altered tRNA expression profile associated with codon-specific proteomic changes in the suicide brain.Molecular psychiatry · 2025Article
- Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing.eLife · 2025Article
- Transfer RNA acetylation regulates in vivo mammalian stress signaling.Science advances · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
23 authors at 7 institutions in 1 country.
J BlazeDepartment of Neuroscience, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.
A NavickasDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
H L PhillipsDepartments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, Upstate Medical University, Syracuse, NY, USA.
S HeisselThe Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY, USA.
A Plaza-JenningsDepartment of Psychiatry, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.
S MiglaniDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8075-320X
H AsgharianDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
M FooDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
C D KatanskiDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
C P WatkinsDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Z T PenningtonDepartment of Neuroscience, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.
B JavidfarFriedman Brain Institute, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.
S Espeso-GilFriedman Brain Institute, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-9145-3870
B RostandyThe Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY, USA.
H AlwaseemThe Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY, USA.
C G HahnDepartment of Neurosciences, Thomas Jefferson University, Philadelphia, PA, USA.
H MolinaThe Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY, USA.
D J CaiDepartment of Neuroscience, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-7729-0523
T PanDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
W D YaoDepartments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, Upstate Medical University, Syracuse, NY, USA.ORCID http://orcid.org/0000-0001-5124-1486
H GoodarziDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9648-8949
F HaghighiDepartment of Neuroscience, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.
S AkbarianDepartment of Neuroscience, Icahn School of Medicine at Mt. Sinai, New York, NY, USA. schahram.akbarian@mssm.edu.ORCID http://orcid.org/0000-0001-7700-0891
Allen Institute for Brain Science · USRockefeller University · USUniversity of California, San Francisco · USUniversity of Chicago · USSUNY Upstate Medical University · USIcahn School of Medicine at Mount Sinai · USThomas Jefferson University · US
Funding
REPRESSIVE HISTONE AND DNA METHYLATION IN RODENT DEPRESSION MODELSP50MH096890 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI NESTLER, ERIC J. · 2012 to 2021
$20.2MCircuit Mechanisms of Retrospective Memory-LinkingR01MH120162 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Denise Jade Cai · 2020 to 2026
$3.9MHow does the brain maximize storage capacity?DP2MH122399 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, DENISE JADE · 2019 to 2020
$2.6MNeurodevelopmental Phenotypes in MLL mutant miceR01MH104341 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM · 2015 to 2019
$2.1MEpigenomic Regulation of a Large, Neuron-specific Chromatin DomainR01MH117790 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM · 2018 to 2022
$2.1MNonproteolytic Polyubiquitin Chains at the SynapseR01MH106489 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI YAO, WEI-DONG · 2015 to 2019
$2.1MRNA cytosine methylation in the rodent prefrontal cortexF32MH115565 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BLAZE, JENNIFER · 2018 to 2020
$188kDNA Methylation and Inflammatory Signatures Associated with Suicide Risk and Treatment in US VeteransI01CX001395 · VA · JAMES J PETERS VA MEDICAL CENTER · PI HAGHIGHI, FATEMEH G · 2017 to 2023
–CSRD VA I01 CX001395CSRD VA IK6 CX002074NIMH NIH HHS DP2 MH122399NIMH NIH HHS F32 MH115565NIMH NIH HHS P50 MH096890NIMH NIH HHS R01 MH104341NIMH NIH HHS R01 MH106489NIMH NIH HHS R01 MH117790NIMH NIH HHS R01 MH120162
Abstract
Epitranscriptomic mechanisms linking tRNA function and the brain proteome to cognition and complex behaviors are not well described. Here, we report bi-directional changes in depression-related behaviors after genetic disruption of neuronal tRNA cytosine methylation, including conditional ablation and transgene-derived overexpression of Nsun2 in the mouse prefrontal cortex (PFC). Neuronal Nsun2-deficiency was associated with a decrease in tRNA m
Indexed as
AnimalsDepressive DisorderEpigenesis, GeneticGene Expression ProfilingMethyltransferasesMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNeuronsPrefrontal CortexProteomeProteomicsRNA, TransferSignal TransductionSynaptic TransmissionMethyltransferasesMisu protein, mouseProteomeRNA, Transfer
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.