Evidence map›Paper›PMID 34390107›Full record

ArticleCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2022

Safety of the transradial approach to carotid stenting.

Young Erben, James F Meschia, Donald V Heck, Fayaz A Shawl, Minerva Mayorga-Carlin, George Howard, Kenneth Rosenfield, John D Sorkin, Thomas G Brott, Brajesh K Lal

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Transradial versus transfemoral access in carotid artery stenting: A meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Young ErbenDivision of Vascular and Endovascular Surgery, Mayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0002-1571-6955
James F MeschiaDepartment of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
Donald V HeckDepartment of Radiology, Novant Health Forsyth Radiological Associates and Triad Radiology Associates, Winston-Salem, North Carolina, USA.
Fayaz A ShawlDepartment of Medicine, Washington Adventist/White Oak Medical Center, Silver Spring, Maryland, USA.
Minerva Mayorga-CarlinDepartment of Vascular Surgery, University of Maryland, Baltimore, Maryland, USA.
George HowardDepartment of Biostatistics and Epidemiology, School of Public Health, University of Alabama, Birmingham, Alabama, USA.
Kenneth RosenfieldDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
John D SorkinBaltimore VA Geriatrics Research, Education, and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA.
Thomas G BrottDepartment of Neurology, Mayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0002-1266-0941
Brajesh K LalDepartment of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
Jacksonville College · USUniversity of Maryland, Baltimore · USAdventist HealthCare · USAlabama Department of Public Health · USMassachusetts General Hospital · USNovant Health · US

Funding

CREST-2 Clinical Coordinating CenterU01NS080168 · NINDS · MAYO CLINIC JACKSONVILLE · PI Thomas G Brott, JAMES F MESCHIA · 2014 to 2026
$56.3M
NSTN National Clinical Coordinating CenterU01NS086872 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Pooja Khatri · 2013 to 2026
$32.3M
CREST-2 Statistical and Data Coordinating Center - SDCCU01NS080165 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI EDWARDS, LLOYD J · 2014 to 2025
$15.0M
Centers for Medicare and Medicaid ServicesNIH HHSNINDS NIH HHS U01 NS080165NINDS NIH HHS U01 NS080168NINDS NIH HHS U01 NS086872
6 · The paper itself

Abstract

backgroundThe multicenter prospective CREST-2 Registry (C2R) provides recent experience in performing carotid artery stenting (CAS) for interventionists to ensure safe performance of CAS.

objectiveTo determine the periprocedural safety of CAS performed using a transradial approach relative to CAS performed using a transfemoral approach.

methodsPatients with ≥70% asymptomatic and ≥50% symptomatic carotid stenosis, ≤80 years of age and at standard or high risk for carotid endarterectomy (CEA) are eligible for the C2R. The primary endpoint was a composite of severe access-related complications. Comparisons were made using propensity-score matched logistic regression.

resultsThe mean age of the cohort was 67.6 ± 8.2 years and 1906 (35.1%) were female. Indications for CAS included 4063 (74.9%) for primary atherosclerosis. A total of 2868 (52.8%) cases underwent CAS for asymptomatic disease. Transradial access was used in 213 (3.9%) patients. The transradial cohort had lower use of general anesthesia (1.5% vs. 6.3%, p = 0.007) and higher use of distal embolic protection (96.7% vs. 89.4%, p = 0.0004). There were no significant differences between radial and femoral access groups in terms of a composite of major access-related complications (0% vs. 1.1%) or a composite of periprocedural stroke or death (3.3% vs. 2.4%; OR = 1.4 [confidence intervals 0.6, 3.1]; p = 0.42).

conclusionWe found no significant differences in rates of major access-related complications or periprocedural stroke or death with CAS performed using transradial compared to transfemoral access. Our results support incorporation of the transradial approach to clinical trials comparing CAS to other revascularization techniques.

Indexed as

Carotid StenosisEndarterectomy, CarotidStrokeAgedFemaleHumansMiddle AgedProspective StudiesStentsTreatment Outcomecarotid artery diseasecerebrovascular diseaseinterventioninterventional devices/innovationstentingstroketechnique

Identifiers

PMID34390107
PMCPMC8840995
OpenAlexW3190318856

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.