Evidence map›Paper›PMID 34390367›Full record

ArticleAnnals of hematology2021

Early and late stage MPN patients show distinct gene expression profiles in CD34

Julian Baumeister, Tiago Maié, Nicolas Chatain, Lin Gan, Barbora Weinbergerova, Marcelo A S de Toledo, Jörg Eschweiler, Angela Maurer, Jiri Mayer, Blanka Kubesova and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Annals of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Julian BaumeisterDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Tiago MaiéCenter for Integrated Oncology, Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, Germany.
Nicolas ChatainDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Lin GanIZKF Genomics Core Facility, RWTH Aachen University Medical School, Aachen, Germany.
Barbora WeinbergerovaDepartment of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic.
Marcelo A S de ToledoDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Jörg EschweilerDepartment of Orthopedic Surgery, University Hospital RWTH Aachen, Aachen, Germany.
Angela MaurerDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Jiri MayerDepartment of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic.
Blanka KubesovaDepartment of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic.
Zdenek RacilInstitute of Hematology and Blood Transfusion, Prague, Czech Republic.
Andreas SchuppertCenter for Integrated Oncology, Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, Germany.
Ivan CostaCenter for Integrated Oncology, Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, Germany.
Steffen KoschmiederDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Tim H BrümmendorfDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Deniz GezerDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany. dgezer@ukaachen.de.
RWTH Aachen University · DEMasaryk University · CZInstitute of Haematology and Blood Transfusion · CZUniversity Hospital Brno · CZ

Funding

deutsche forschungsgemeinschaft BR1782/5-1deutsche forschungsgemeinschaft GE2811/4-1deutsche forschungsgemeinschaft KO2155/6-1deutsche forschungsgemeinschaft KO2155/7-1interdisziplinäres zentrum für klinische forschung, universitätsklinikum würzburg grant O1-6ministerstvo zdravotnictví ceské republiky 00023736ministerstvo zdravotnictví ceské republiky 65269705
6 · The paper itself

Abstract

Myeloproliferative neoplasms (MPN), comprising essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF), are hematological disorders of the myeloid lineage characterized by hyperproliferation of mature blood cells. The prediction of the clinical course and progression remains difficult and new therapeutic modalities are required. We conducted a CD34

Indexed as

TranscriptomeAntigens, CD34Gene Expression Regulation, NeoplasticHumansMyeloproliferative DisordersPolycythemia VeraPrimary MyelofibrosisThrombocythemia, EssentialAntigens, CD34CD34Gene expressionJAK2V617FMPN

Identifiers

PMID34390367
PMCPMC8592960
OpenAlexW3192852744

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.