Evidence map›Paper›PMID 34393786›Full record

ArticleFrontiers in pharmacology2021

Chronoeffects of the Herbal Medicines

Jinming Liu, Haiman Xu, Li Zhang, Shuai Wang, Danyi Lu, Min Chen, Baojian Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jinming LiuDepartment of Critical Care Medicine, Zhongshan Torch Development Zone Hospital, Zhongshan, China.
Haiman XuCollege of Pharmacy, Jinan University, Guangzhou, China.
Li ZhangCollege of Pharmacy, Jinan University, Guangzhou, China.
Shuai WangCollege of Pharmacy, Jinan University, Guangzhou, China.
Danyi LuCollege of Pharmacy, Jinan University, Guangzhou, China.
Min ChenCollege of Pharmacy, Jinan University, Guangzhou, China.
Baojian WuInstitute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identifying drugs with dosing time-dependent effects (chronoeffects) and understanding the underlying mechanisms would help to improve drug treatment outcome. Here, we aimed to determine chronoeffects of the herbal medicines Puerariae radix (PR) and Coptidis rhizoma (CR), and investigate a potential role of REV-ERBα as a drug target in generating chronoeffects. The pharmacological effect of PR on hyperhomocysteinemia in mice was evaluated by measuring total homocysteine, triglyceride levels and lipid accumulation. PR dosed at ZT10 generated a stronger effect on hyperhomocysteinemia than drug dosed at ZT2. Furthermore, PR increased the expression levels of REV-ERBα target genes

Indexed as

chronic colitischronoefficacycoptidis rhizomadosing timehyperhomocysteinemiapuerariae radix

Identifiers

PMID34393786
PMCPMC8355589

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.