Evidence map›Paper›PMID 34394832›Full record

ArticleOxidative medicine and cellular longevity2021

Oxypaeoniflorin Prevents Acute Lung Injury Induced by Lipopolysaccharide through the PTEN/AKT Pathway in a Sirt1-Dependent Manner.

Fan Guohua, Zhu Tieyuan, Wang Rui, Xiong Juan

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Fan Guohua *Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, China.
Zhu Tieyuan *Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, China.
Wang RuiDepartment of Emergency, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, China.ORCID https://orcid.org/0000-0003-4946-0529
Xiong JuanDepartment of Thoracic Surgery, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, China.ORCID https://orcid.org/0000-0001-8291-7258
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI) is featured by pulmonary edema, alveolar barrier injury, inflammatory response, and oxidative stress. The activation of Sirt1 could relieve lipopolysaccharide- (LPS-) induced murine ALI by maintaining pulmonary epithelial barrier function. Oxypaeoniflorin (Oxy) serves as a major component of

Indexed as

Acute Lung InjuryAnimalsDisease Models, AnimalDrugs, Chinese HerbalLipopolysaccharidesLungMaleMiceMice, Inbred C57BLOxidative StressProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseSignal TransductionSirtuin 1Tumor Necrosis Factor-alphaDrugs, Chinese HerbalLipopolysaccharidesoxypaeonifloraProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseSirtuin 1Tumor Necrosis Factor-alpha

Identifiers

PMID34394832
PMCPMC8357472
OpenAlexW3190207717

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.