ArticleHealth SA = SA Gesondheid2021
Chemotherapy-related subjective cognitive impairment in breast cancer patients in semi-rural South Africa.
Article in Health SA = SA Gesondheid, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Cancer treatment-related cognitive impairment.Neuro-oncology advances · 2026Review
- Implications of Cyclophosphamide, Methotrexate, and 5-Flurouracil Chemotherapy on Hippocampal-Dependent Cognition and Gut-Microbiome.Frontiers in microbiomes · 2025Article
- Acute and long-term effects of chemotherapy on cognitive function among Indian breast cancer patients.Ecancermedicalscience · 2025Article
- A scoping review of cognitive assessment tools and domains for chemotherapy-induced cognitive impairments in cancer survivors.Frontiers in human neuroscience · 2023Article
- Physiological and cognitive changes after treatments of cyclophosphamide, methotrexate, and fluorouracil: implications of the gut microbiome and depressive-like behavior.Frontiers in neuroscience · 2023Article
- Chemobrain in Breast Cancer: Mechanisms, Clinical Manifestations, and Potential Interventions.Drug safety · 2022Review
- The COMT Genetic Factor Regulates Chemotherapy-Related Prospective Memory Impairment in Survivors With HER2-/+ Breast Cancer.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast cancer is the most commonly diagnosed cancer amongst women worldwide. Whilst current evidence indicates the therapeutic benefits from the use of chemotherapy, self-perceived cognitive difficulties emerged as a frequent occurrence during and after chemotherapy treatment in breast cancer patients.
aimThe current study sought to investigate self-perceived cognitive impairment in a group of breast cancer patients in semi-rural South Africa.
settingThe patients were recruited from an outpatient oncology clinic at a semi-rural, tertiary academic hospital in Gauteng, South Africa.
methodsIn a randomised, quantitative, time-based series study, 30 female patients aged 21-60 years (mean age = 50 years) diagnosed with stages II and III breast cancer on CMF (cyclophosphamide, methotrexate, fluorouracil) (
resultsThe results of the paired sample
conclusionThis study confirms that self-reported subjective cognitive impairment is common in breast cancer patients who received chemotherapy in a sample of South African patients. The results have implications for the overall care of cancer patients. CONTRIBUTION: The context-based knowledge engendered by the current study is expected to augment the continuum of care for breast cancer patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.