ArticleScientific reports2021
Evaluation of the association between periodontitis and risk of Parkinson's disease: a nationwide retrospective cohort study.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Metabolic Syndrome and Incidence of Parkinson Disease: A Community-Based Longitudinal Study and Meta-Analysis.Neurology · 2025Pooled it
- Association between metabolic syndrome and the risk of Parkinson's disease: a meta-analysis.BMC neurology · 2024Pooled it
- Is There an Association Between Parkinson's Disease and Periodontitis? A Systematic Review and Meta-Analysis.Journal of Parkinson's disease · 2023Pooled it
- The Oral-Brain Axis: Mechanistic Insights Linking Periodontitis With Alzheimer's and Parkinson's Diseases.Cureus · 2026Review
- Impact of Oral Immunity on Neuroinflammation and Neurodegenerative Diseases.Advances in experimental medicine and biology · 2026Review
- Periodontitis and Parkinson's disease: a narrative review of associations, proposed mechanisms, and clinical considerations.Frontiers in oral health · 2026Review
- Evaluating dental health in patients with different severity of Parkinson's disease: a cross-sectional study.BMC oral health · 2025Article
- Unraveling brain aging through the lens of oral microbiota.Neural regeneration research · 2025Article
- Review
- Oral Microbiome: A Review of Its Impact on Oral and Systemic Health.Microorganisms · 2024Review
- Periodontitis: A Plausible Modifiable Risk Factor for Neurodegenerative Diseases? A Comprehensive Review.International journal of molecular sciences · 2024Review
- Investigating the Connection between Chronic Periodontitis and Parkinson's Disease: Findings from a Korean National Cohort Study.Biomedicines · 2024Article
- The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease.Science advances · 2023Article
- Periodontal Pathogens and Their Links to Neuroinflammation and Neurodegeneration.Microorganisms · 2023Review
- Periodontal health in a population with Parkinson's disease in Spain: a cross-sectional study.Medicina oral, patologia oral y cirugia bucal · 2023Article
- Better oral hygiene is associated with a reduced risk of osteoporotic fracture: a nationwide cohort study.Frontiers in endocrinology · 2023Article
- Better Oral Hygiene Is Associated with a Decreased Risk of Meniere's Disease: A Nationwide Cohort Study.Journal of personalized medicine · 2022Article
- Research progress on the relationship between chronic periodontitis and Parkinson's disease.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to examine the association between periodontitis and risk of incident Parkinson's disease using large-scale cohort data on the entire population of South Korea. Health checkup data from 6,856,180 participants aged 40 and older were provided by the National Health Insurance Service of South Korea between January 1, 2009, and December 31, 2009, and the data were followed until December 31, 2017. The hazard ratio (HR) of Parkinson's disease and 95% confidence interval (CI) were estimated using a Cox proportional hazards model adjusted for potential confounders. The incidence probability of Parkinson's disease was positively correlated with the presence of periodontitis. The HR of Parkinson's disease for the participants without the need of further dentist visits was 0.96 (95% CI 0.921-1.002); the HR of Parkinson's disease increased to 1.142 (95% CI 1.094-1.193) for the individuals who needed further dentist visits. Compared to individuals without periodontitis and without metabolic syndrome, the HR of incident Parkinson's disease gradually increased for individuals with periodontitis, with metabolic syndrome, and with both periodontitis and metabolic syndrome. People with periodontitis and metabolic syndrome had the highest HR of incident Parkinson's disease, at 1.167 (95% CI 1.118-1.219). In conclusion, a weak association between periodontitis and Parkinson's disease was suggested after adjusting for confounding factors from the population-based large-scale cohort of the entire South Korean population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.