Evidence map›Paper›PMID 34403018›Full record

SynthesisJournal of assisted reproduction and genetics2021

Replication study and meta-analysis of selected genetic variants and polycystic ovary syndrome susceptibility in Asian population.

Pengcheng Wan, Linghan Meng, Chao Huang, Baosheng Dai, Yuchen Jin, Longlong Chai, Xiuli Gu, Bifeng Chen, Song Quan

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  4. Article
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  6. Pharmacogenomic of LH and its receptor: are we ready for clinical practice?Reproductive biology and endocrinology : RB&E · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Pengcheng Wan *Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Linghan Meng *Department of Biotechnology, Institute of WUT-AMU, Wuhan University of Technology, Wuhan, 430070, China.
Chao HuangDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China.
Baosheng DaiClinical Laboratory Center, People's Hospital of Hubei, Wuhan University, Wuhan, 430072, China.
Yuchen JinDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China.
Longlong ChaiDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China.
Xiuli GuDepartment of Reproductive Genetics, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430032, China.
Bifeng ChenDepartment of Biotechnology, Institute of WUT-AMU, Wuhan University of Technology, Wuhan, 430070, China. cbifeng@whut.edu.cn.ORCID http://orcid.org/0000-0001-5482-1910
Song QuanCenter for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. quansong@smu.edu.cn.
Wuhan University of Technology · CNNanfang Hospital · CNHuazhong University of Science and Technology · CNWuhan University · CN

Funding

Fundamental Research Funds for the Central Universities WUT: 2020IB029National Key R&D Program of China 2018YFC1004402Natural Science Foundation of Hubei Province 2019CFB756
6 · The paper itself

Abstract

purposePolycystic ovary syndrome (PCOS) is a highly complex disorder influenced by genetic and environmental factors. Previous association studies have identified multiple PCOS-susceptible loci, but there is no consistent conclusion, which calls for further investigations.

methodsIn the present case-control study, FSHR gene variants (rs2268361, rs6165, and rs6166), LHCGR gene variant (rs13405728), THADA gene variant (rs13429458), DENND1A gene variants (rs10818854 and rs2479106), and INSR gene variants (rs2059807 and rs1799817) were genotyped with Sanger sequencing in a total of 400 PCOS women and 480 healthy women.

resultsAfter Bonferroni correction, our results showed that rs13405728, rs13429458, rs2479106, rs10818854, and rs2059807 were significantly associated with PCOS risk in Chinese women. To improve the statistical strength, a further meta-analysis in Asian population was conducted. Although rs6166 and rs1799817 were not associated with PCOS risk in the present study, they were identified to be strongly associated with PCOS risk in the pooled Koreans and Chinese respectively. No significant association with PCOS risk was consistently found for rs2268361 or rs6165. Moreover, the pooled results further confirmed the significant association with PCOS risk for rs13405728, rs13429458, rs2479106, rs10818854, and rs2059807.

conclusionsCollectively, the rs6166, rs13405728, rs13429458, rs2479106, rs10818854, rs2059807, and rs1799817 may indeed be the genetic risk factors for PCOS in Asian population, which requires further investigation using larger independent sets of samples in different ethnic populations.

Indexed as

Genetic MarkersGenetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAsiaAsian PeopleCase-Control StudiesFemaleGenome-Wide Association StudyHumansPolycystic Ovary SyndromeGenetic MarkersGenetic susceptibilityMeta-analysisPolycystic ovary syndrome (PCOS)Variant

Identifiers

PMID34403018
PMCPMC8581112
OpenAlexW3194732609

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.