Evidence map›Paper›PMID 34404749›Full record

ArticleeNeuro

Modeling Neurodevelopmental Disorders and Epilepsy Caused by Loss of Function of

Michèle Partoens, Ann-Sofie De Meulemeester, Hoi-Khoanh Giong, Duc-Hung Pham, Jeong-Soo Lee, Peter A de Witte, Aleksandra Siekierska

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Habituation learning: insights from zebrafish larvae.Frontiers in molecular neuroscience · 2025
    Review
  3. Article
  4. Article
  5. Connectivity Mapping Using a NovelFrontiers in molecular neuroscience · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Michèle PartoensLaboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
Ann-Sofie De MeulemeesterLaboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-8490-5816
Hoi-Khoanh GiongDisease Target Structure Research Centre, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Duc-Hung PhamLaboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
Jeong-Soo LeeDisease Target Structure Research Centre, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Peter A de WitteLaboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium peter.dewitte@kuleuven.be.
Aleksandra SiekierskaLaboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0003-4907-605X
KU Leuven · BEUniversity of Science and Technology · YE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years there has been extensive research on malformations of cortical development (MCDs) that result in clinical features like developmental delay, intellectual disability, and drug-resistant epilepsy (DRE). Various studies highlighted the contribution of microtubule-associated genes (including tubulin and kinesin encoding genes) in MCD development. It has been reported that

Indexed as

EpilepsyIntellectual DisabilityAnimalsKinesinsMiceRepressor ProteinsTubulinZebrafishKIF2A protein, mouseKinesinsRepressor ProteinsTubulindrug-resistant epilepsyKIF2Amalformations of cortical developmentseizureszebrafish

Identifiers

PMID34404749
PMCPMC8425962
OpenAlexW3196173555

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.