ArticleScientific reports2021
Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Anterior Segment Optical Coherence Tomography with Angiography for the Cornea and Ocular Surface.Journal of clinical medicine · 2026Review
- Clinical application of anterior segment optical coherence tomography in ocular emergencies: A comprehensive review.The Journal of international medical research · 2025Review
- Current clinical applications of anterior segment optical coherence tomography angiography: a review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Review
- Recent advances in optical coherence tomography for anterior segment imaging in small animals and their clinical implications.The ocular surface · 2022Review
- Concentration-associated pathology of alkali burn in a mouse model using anterior segment optical coherence tomography with angiography.Experimental eye research · 2022Article
- The role of Tenonplasty in the management of limbal and scleral ischemia due to acute ocular chemical burns.Indian journal of ophthalmology · 2022Review
- Role of AS-OCT in Managing Corneal Disorders.Diagnostics (Basel, Switzerland) · 2022Review
- Role of Anterior Segment-Optical Coherence Tomography Angiography in Acute Ocular Burns.Diagnostics (Basel, Switzerland) · 2022Review
- Anterior Segment Optical Coherence Tomography Angiography Following Trabecular Bypass Minimally Invasive Glaucoma Surgery.Frontiers in medicine · 2022Article
- Demographic, Clinical Profile and Management Outcomes of Ocular Chemical Injuries in Saudi Children.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the use of anterior segment-optical coherence tomography angiography (AS-OCTA) in the assessment of limbal ischemia in an animal model chemical ocular injury. We conducted a prospective study using an established chemical ocular injury model in 6 rabbits (12 eyes), dividing the cornea limbus into 4 quadrants. Chemical injury grade was induced based on extent of limbal injury (0 to 360 degrees) and all eyes underwent serial slit-lamp with AS-OCTA imaging up to one month. Main outcome measure was changes in AS-OCTA vessel density (VD) comparing injured and control cornea limbal quadrants within 24 h and at one month. AS-OCTA was able to detect differences in limbal VD reduction comparing injured (3.3 ± 2.4%) and control quadrants (7.6 ± 2.3%; p < 0.001) within 24 h of ocular chemical injury. We also observed that AS-OCTA VD reduction was highly correlated with the number of quadrants injured (r = - 0.89; p < 0.001; 95% CI - 5.65 to - 1.87). Corneal vascularization was detected by AS-OCTA in injured compared to control quadrants (10.1 ± 4.3% vs 7.0 ± 1.2%; p = 0.025) at 1 month. Our animal pilot study suggests that AS-OCTA was able to detect limbal vessel disruption from various severities of acute chemical insult, and in the future, could potentially serve as an adjunct in providing objective grading of acute ocular chemical injury once validated in a clinical trial.
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