Evidence map›Paper›PMID 34407229›Full record

ArticleJournal of cellular biochemistry2021

PKD1 alleviates oxidative stress-inhibited osteogenesis of rat bone marrow-derived mesenchymal stem cells through TAZ activation.

Tongtong Chen, Hanqi Wang, Chaoyin Jiang, Yong Lu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. The Important Role of Polycystin in the Skeletal System.Calcified tissue international · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Molecular and Cellular Mechanisms of Osteoporosis.International journal of molecular sciences · 2023
    Review
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tongtong ChenDepartment of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Hanqi WangDepartment of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Chaoyin JiangDepartment of Orthopedic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
Yong LuDepartment of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.ORCID 0000-0001-8522-617X
Ruijin Hospital · CNShanghai Sixth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress is known to inhibit osteogenesis and PKD1 is implicated in bone remodeling and skeletogenesis. In the present study, we explored the role of PKD1 in osteogenesis under oxidative stress. H

Indexed as

AnimalsCell DifferentiationCells, CulturedCell SurvivalCore Binding Factor Alpha 1 SubunitGene Expression RegulationGenes, mycHydrogen PeroxideMesenchymal Stem CellsOsteogenesisOxidative StressRatsRats, WistarSirtuin 1Transcriptional Coactivator with PDZ-Binding Motif ProteinsTRPP Cation ChannelsCore Binding Factor Alpha 1 SubunitHydrogen PeroxideRunx2 protein, ratSirt1 protein, ratSirtuin 1Transcriptional Coactivator with PDZ-Binding Motif ProteinsTRPP Cation ChannelsWWTR1 protein, ratbone marrow-derived mesenchymal stem cellsosteogenesisPKD1Sirt1TAZ

Identifiers

PMID34407229
PMCPMC9292359
OpenAlexW3193894115

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.