ReviewInternational journal of radiation oncology, biology, physics2022
Mechanisms and Review of Clinical Evidence of Variations in Relative Biological Effectiveness in Proton Therapy.
Review in International journal of radiation oncology, biology, physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Definitive proton therapy for unresectable trunk soft tissue sarcoma: a single-institution prospective registry-based cohort study.Clinical and translational radiation oncology · 2026Article
- Tissue-level RBE determination and normal lung responses along the proton SOBP.Radiation oncology (London, England) · 2026Article
- The Radiobiological Effect of Flattening Filter Free (FFF) Beam Delivery Parameters on A549 and MCF-7 Cell Survival: An In Vitro Study.Life (Basel, Switzerland) · 2026Article
- Technical Considerations on Proton Therapy in NRG's Multi-Institutional Clinical Trials.International journal of radiation oncology, biology, physics · 2026Article
- Enable preclinical, high-precision image-guided radiotherapy research with a stand-alone small animal IGRT system.Medical physics · 2026Article
- A Monte Carlo study of proton LET calculations: Comparison between the codes PENHAN, FLUKA, and TOPAS.Medical physics · 2026Article
- Dose- and time-dependent relative biological effect of proton in different intracerebral cells.Scientific reports · 2026Article
- Commissioning of a Monte Carlo-based scanning proton beam for breast cancer: Incorporating LETd calculations and variable RBE models.Journal of applied clinical medical physics · 2026Article
- Poly ADP Ribose Polymerase Inhibitors Potentiate Proton Therapy End-of-Range Effects by Accelerating Replication Forks and Promoting Transcription Conflict.International journal of radiation oncology, biology, physics · 2026Article
- Relative Biological Effectiveness-Clinical Practice at US Proton Therapy Centers.International journal of particle therapy · 2025Article
- Extending the microdosimetry gamma model (MGM) to estimate induced DNA damage and its complexity at macroscopic scale by protons and helium ions.Physics in medicine and biology · 2025Article
- Variable Relative Biological Effectiveness of Protons in the Rat Spinal Cord: Measurements and Comparison With Model Calculations.Advances in radiation oncology · 2025Article
- Comparison of proton and photon therapy in stereotactic arrhythmia radioablation for ventricular tachycardia.Physics and imaging in radiation oncology · 2025Article
- Evaluating the technical feasibility of biology-guided dose painting in proton therapy.Physics and imaging in radiation oncology · 2025Article
- Commissioning of a precision preclinical 200 kV x-ray irradiator based on modular adaptations.Medical physics · 2025Article
- Embracing the Future of Clinical Trials in Radiation Therapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions.International journal of radiation oncology, biology, physics · 2025Review
- Comparison of the effects of IMRT and IMPT on MRI features of normal brain tissue: a retrospective study.BMC medical imaging · 2025Article
- Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patients.Clinical and translational radiation oncology · 2025Article
- Linear approximation of variable relative biological effectiveness models for proton therapy.Physics and imaging in radiation oncology · 2025Article
- Recommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness.Physics and imaging in radiation oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Proton therapy is increasingly being used as a radiation therapy modality. There is uncertainty about the biological effectiveness of protons relative to photon therapies as it depends on several physical and biological parameters. Radiation oncology currently applies a constant and generic value for the relative biological effectiveness (RBE) of 1.1, which was chosen conservatively to ensure tumor coverage. The use of a constant value has been challenged particularly when considering normal tissue constraints. Potential variations in RBE have been assessed in several published reviews but have mostly focused on data from clonogenic cell survival experiments with unclear relevance for clinical proton therapy. The goal of this review is to put in vitro findings in relation to clinical observations. Relevant in vivo pathways determining RBE for tumors and normal tissues are outlined, including not only damage to tumor cells and parenchyma but also vascular damage and immune response. Furthermore, the current clinical evidence of varying RBE is reviewed. The assessment can serve as guidance for treatment planning, personalized dose prescriptions, and outcome analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.