Evidence map›Paper›PMID 34408277›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021

α2-containing γ-aminobutyric acid type A receptors promote stress resiliency in male mice.

Rebecca S Benham, Catherine Choi, Nathaniel W Hodgson, Nishani B Hewage, Rahel Kastli, Rachel J Donahue, John W Muschamp, Elif Engin, William A Carlezon, Takao K Hensch and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. The role of GABANeuroscience and biobehavioral reviews · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. GABATrends in pharmacological sciences · 2023
    Review
  11. Article
  12. GABAFrontiers in psychiatry · 2022
    Review
  13. Repeated inhibition of sigma-1 receptor suppresses GABAFrontiers in molecular neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Rebecca S BenhamLaboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA, USA.
Catherine ChoiLaboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA, USA.
Nathaniel W HodgsonF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Nishani B HewageLaboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA, USA.
Rahel KastliLaboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA, USA.ORCID http://orcid.org/0000-0002-3810-6228
Rachel J DonahueDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
John W MuschampDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Elif EnginLaboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA, USA.
William A CarlezonDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4162-3947
Takao K HenschF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0748-8152
Uwe RudolphLaboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA, USA. urudolph@illinois.edu.ORCID http://orcid.org/0000-0001-9396-4746
Harvard University · USBoston Children's Hospital · US

Funding

Res Support CoreP50MH094271 · NIMH · HARVARD UNIVERSITY · PI LICHTMAN, JEFF W · 2011 to 2022
$18.6M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Roles of nuleus accumbens CREB and Kappa function in depressionR01MH063266 · NIMH · MC LEAN HOSPITAL (BELMONT, MA) · PI CARLEZON, WILLIAM A. · 2001 to 2025
$9.1M
SPP1, Oxidative Stress, and Lead ToxicityR01ES029097 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI LU, QUAN · 2018 to 2022
$2.8M
A GABA Pathway to Faster Acting AntidepressantsR01MH095905 · NIMH · MCLEAN HOSPITAL · PI RUDOLPH, UWE · 2012 to 2016
$2.0M
Intrahippocampal dynamics underlying cognitive rigidityK01MH107787 · NIMH · MCLEAN HOSPITAL · PI ENGIN, ELIF · 2016 to 2019
$696k
NICHD NIH HHS P50 HD105351NIEHS NIH HHS R01 ES029097NIMH NIH HHS K01 MH107787NIMH NIH HHS P50 MH094271NIMH NIH HHS R01 MH063266NIMH NIH HHS R01 MH095905
6 · The paper itself

Abstract

Brain α2-containing GABA

Indexed as

AnxietyReceptors, GABAAnimalsgamma-Aminobutyric AcidMaleMiceMice, Inbred C57BLReceptors, Dopamine D1Receptors, GABA-AGabra2 protein, mousegamma-Aminobutyric AcidReceptors, Dopamine D1Receptors, GABAReceptors, GABA-A

Identifiers

PMID34408277
PMCPMC8505491
OpenAlexW3195042344

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.