Evidence map›Paper›PMID 34409109›Full record

ArticleBioMed research international2021

Therapeutic Effect of Murine Bone Marrow-Derived Mesenchymal Stromal/Stem Cells and Human Placental Extract on Testicular Toxicity Resulting from Doxorubicin in Rats.

Mervat Ahmed AbdRabou, Ahmed B M Mehany, Islam M Farrag, Amany Belal, Othman F Abdelzaher, Abdou El-Sharkawy, Asmaa M Abd El-Azez, Salah M El-Sharkawy, Manal H Al Badawi

Abstract read
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In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mervat Ahmed AbdRabouBiology Department, College of Science, Jouf University, P.O. Box 2014, Sakaka, Saudi Arabia.ORCID https://orcid.org/0000-0001-6031-8799
Ahmed B M MehanyZoology Department Faculty of Science, Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-9913-5380
Islam M FarragForensic Medicine and Clinical Toxicology, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.
Amany BelalDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID https://orcid.org/0000-0003-1045-0163
Othman F AbdelzaherZoology Department Faculty of Science, Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-0101-2962
Abdou El-SharkawyDepartment of Anatomy, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-9304-5309
Asmaa M Abd El-AzezZoology Department, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-4293-8446
Salah M El-SharkawyZoology Department Faculty of Science, Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-8446-2653
Manal H Al BadawiDepartment of Anatomy, Faculty of Medicine, Helwan University, Helwan, Egypt.ORCID https://orcid.org/0000-0001-5775-0775

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oncotherapeutics like doxorubicin can affect male gonads; as a result, it leads to infertility. This work was conducted to demonstrate the toxic effects of doxorubicin on testes of male albino rats. Fifty male albino rats aged 5-7 weeks were used in this study. The animals were randomly separated into 5 sets (each set containing ten rats). Group I received saline (i.p.) for 4 weeks. Group II was given doxorubicin (DOX), 5 mg/kg BW (i.p.) once/week for 4 weeks. Groups III and IV were treated in the same way as the DOX group, left for one week without medication, and then injected with mesenchymal stromal cells (MSCs) or human placental extract (HPE) therapy in a single dose of 5 × 10

Indexed as

AnimalsCombined Modality TherapyDoxorubicinFemaleFollicle Stimulating HormoneHumansLuteinizing HormoneMaleMesenchymal Stem Cell TransplantationMicePlacental ExtractsPregnancyRatsTestisTestosteroneDoxorubicinFollicle Stimulating HormoneLuteinizing HormonePlacental ExtractsTestosterone

Identifiers

PMID34409109
PMCPMC8367585

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.