SynthesisEuropean journal of medical research2021
The effects of hyperbaric oxygen therapy (HBOT) on coronavirus disease-2019 (COVID-19): a systematic review.
Synthesis in European journal of medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Auditory Acclimatization in New Adult Hearing Aid Users: A Registered Systematic Review of Magnitude, Key Variables, and Clinical Relevance.Journal of speech, language, and hearing research : JSLHR · 2025Pooled it
- Efficacy and safety of hyperbaric oxygen therapy for fibromyalgia: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Advances in Hyperbaric Oxygen Therapy: Medical Benefits and Technical Perspectives.Annals of biomedical engineering · 2026Article
- The impact of hyperbaric therapy on cognitive functions in patients treated for idiopathic sudden hearing loss or hard-to-heal chronic wounds.Scientific reports · 2026Article
- Knowledge, attitudes, and decision-making regarding hyperbaric oxygen-assisted cancer treatment among related healthcare professionals.Frontiers in oncology · 2026Article
- Hyperoxia: Effective Mechanism of Hyperbaric Treatment at Mild-Pressure.International journal of molecular sciences · 2024Review
- COVID-19-Induced Acute Respiratory Distress Syndrome Treated with Hyperbaric Oxygen: Interim Safety Report from a Randomized Clinical Trial (COVID-19-HBO).Journal of clinical medicine · 2023Article
- Cost Effectiveness of Strategies for Caring for Critically Ill Patients with COVID-19 in Tanzania.PharmacoEconomics - open · 2023Article
- Is There a Role for Hyperbaric Oxygen Therapy in Reducing Long-Term COVID-19 Sequelae?Journal of clinical medicine · 2023Article
- Gut microbiota and COVID-19: A systematic review.Health science reports · 2023Article
- Predictors of Core Decompression Success in Patients with Femoral Head Avascular Necrosis.The archives of bone and joint surgery · 2023Article
- Evaluating the effects of air disinfectants in decontamination of COVID-19 aerosols.Health science reports · 2023Article
- Clinico-Epidemiological Profile of COVID-19 Patients with Omicron Variant Admitted in a Tertiary Care Center, South India.International journal of general medicine · 2023Article
- Effects of Smoking on COVID-19 Management and Mortality: An Umbrella Review.Journal of smoking cessation · 2023Review
- Effectiveness of Hyperbaric Oxygen Therapy in SARS-CoV-2 Pneumonia: The Primary Results of a Randomised Clinical Trial.Journal of clinical medicine · 2022Article
- COVID-19 Infection Risk Following Elective Arthroplasty and Surgical Complications in COVID-19-vaccinated Patients: A Multicenter Comparative Cohort Study.Arthroplasty today · 2022Article
- Can Hyperbaric Oxygen Therapy Be Used to Treat Children after COVID-19? A Bibliographic Review.International journal of environmental research and public health · 2022Review
- Article
- Moderate, Little, or No Improvements in Neurobehavioral Symptoms among Individuals with Long COVID: A 34-Country Retrospective Study.International journal of environmental research and public health · 2022Article
- Medical avoidance among marginalized groups: the impact of the COVID-19 pandemic.Journal of behavioral medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxygenation serves as a cornerstone in the treatment of COVID-19, and several methods have been extensively studied so far. Herein, we aimed to systematically review the studies discussing hyperbaric oxygen therapy (HBOT) to examine its reported efficacy and adverse events in patients with COVID-19.
methodsWe systematically searched and retrieved the relevant articles using keywords on the online databases, including PubMed, Scopus, Embase, Web of Science, and Cochrane databases up to April 11th, 2021. The retrieved records underwent a two-step title/abstract and full-text screening process, and the eligible papers were identified. National Institutes of health (NIH) quality assessment tool was used for this study. This study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) with ID CRD42021269821.
resultsEight articles from three countries were included. All the included studies had good and fair quality scores, with no poor studies included in this systematic review (Good: n = 5, Fair: n = 3). Studies were divided into clinical trials and case reports/series. Most of the studies used HBOT less than 1.5-2 absolute atmospheres (ATA) for 90 min sessions and thereafter sessions were decreased to 60 min. Trials demonstrated most of the patients recovered after receiving HBOT, and blood oxygen saturation increased after several sessions of HBOT.
conclusionOverall, HBOT seems to be a safe and effective oxygenation method in patients with COVID-19. However, there is limited knowledge and evidence regarding the effects and mechanism of HBOT in COVID-19 treatment, and further evaluations require extensive well-designed studies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.