Evidence map›Paper›PMID 34412893›Full record

SynthesisFertility and sterility2021

Mean differences in maternal body mass index and recurrent pregnancy loss: a systematic review and meta-analysis of observational studies.

Abey Eapen, Emily T Hayes, Dana B McQueen, Molly Beestrum, Patrick Ten Eyck, Christina Boots

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Fertility and sterility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  4. Review
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  8. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Abey EapenDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Carver College of Medicine, University of Iowa, Iowa City, Iowa. Electronic address: abey-eapen@uiowa.edu.
Emily T HayesDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Dana B McQueenDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Northwestern University, Chicago, Illinois.
Molly BeestrumGalter Health Sciences Library, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Patrick Ten EyckInstitute for Clinical and Translational Science, University of Iowa, Iowa City, Iowa.
Christina BootsDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Northwestern University, Chicago, Illinois.

Funding

The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
NCATS NIH HHS UL1 TR002537
6 · The paper itself

Abstract

objectiveTo investigate the association of maternal body mass index (BMI) and recurrent pregnancy loss (RPL).

designSystematic review and meta-analysis.

settingNot applicable. PATIENT(S): A total of 3,833 women with RPL and 4,083 women as controls. INTERVENTION(S): Studies were identified through a search of PubMed, Embase, Scopus, and Cochrane. MAIN OUTCOME MEASURE(S): The primary outcome of interest was RPL using the mean differences in maternal BMI as the predictor variable. The results of the meta-analysis were reported as the mean difference with a 95% confidence interval. RESULT(S): In total, 892 studies were reviewed. Pooled data from 25 studies suggested that the maternal BMI of women with a history of recurrent pregnancy loss was significantly higher than the BMI of controls, mean difference 0.7 kg/m CONCLUSION(S): These findings supported an association between maternal BMI and RPL. Large prospective studies are needed to evaluate the influence of maternal BMI on pregnancy outcomes in women with RPL.

Indexed as

Body Mass IndexAbortion, HabitualFemaleHumansObesityObservational Studies as TopicPregnancyPregnancy OutcomeRisk AssessmentRisk FactorsBody mass indexobesityrecurrent miscarriagerecurrent pregnancy loss

Identifiers

PMID34412893
PMCPMC8608000

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.